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L7045

L 748337 hydrate

≥98% (HPLC)

Synonym(s):

N-(3-{3-[2-(4-Benzenesulfonylamino-phenyl)-ethylamino]-(2S)-2-hydroxy-propoxy}-benzyl)-acetamide hydrate; Acetamide, N-[[3-[(2S)-2-hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl] hydrate

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About This Item

Empirical Formula (Hill Notation):
C26H31N3O5S · xH2O
Molecular Weight:
497.61 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329817647
MDL number:
MFCD20134197
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assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +4.0 to +8.0°, c = 4 in DMSO

solubility

DMSO: >12 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

SMILES string

O.CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NS(=O)(=O)c3ccccc3)cc2)c1

InChI

1S/C26H31N3O5S.H2O/c1-20(30)28-17-22-6-5-7-25(16-22)34-19-24(31)18-27-15-14-21-10-12-23(13-11-21)29-35(32,33)26-8-3-2-4-9-26;/h2-13,16,24,27,29,31H,14-15,17-19H2,1H3,(H,28,30);1H2/t24-;/m0./s1

InChI key

TYFJHLUOBDKUID-JIDHJSLPSA-N

Biochem/physiol Actions

L 748337 is a β3 adrenergic receptor antagonist
L 748337 is a selective, competitive beta 3 adrenergic receptor antagonist, that binds to the receptor with an affinity of 04 nM. The affinities for beta-1 and beta-2 receptors are 154 and 204 nM, respectively. The compound potently inhibits agonist-stimulated lipolysis in adipocytes, as well as agonist induced relaxation of smooth muscle.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
041M4608V

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Xiaobing Wang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 38(2), 514-530 (2016-02-02)
The role of the β3-adrenergic receptor (β3-AR) agonist BRL37344 in atrial fibrillation (AF) structural remodeling and the underlying mechanisms as a therapeutic target were investigated. Four groups of dogs were evaluated: sham, pacing, β3-AR agonist BRL37344 (β3-AGO), and β3-AR antagonist
Ziwen Wang et al.
Molecular medicine (Cambridge, Mass.), 26(1), 54-54 (2020-06-07)
Our objective was to investigate the efficacy of the beta-3 adrenergic receptor (β3-AR) agonist BRL37344 for the prevention of liver steatosis and inflammation associated with nonalcoholic fatty liver disease (NAFLD). Four groups were established: a control group (given a standard