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Merck
CN

L8170

Pseudolaric Acid B

≥98% (HPLC)

Synonym(s):

(-)-Pseudolaric acid B, O-Acetylpseudolaric acid C, Pseudolarix acid B

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About This Item

Empirical Formula (Hill Notation):
C23H28O8
CAS Number:
82508-31-4
Molecular Weight:
432.46
UNSPSC Code:
12352106
NACRES:
NA.25
MDL number:
MFCD26960905

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Product Name

Pseudolaric Acid B, ≥98% (HPLC)

InChI

1S/C23H28O8/c1-14(17(24)25)6-5-10-21(2)16-9-12-22(19(27)31-21)11-7-15(18(26)29-3)8-13-23(16,22)20(28)30-4/h5-7,10,16H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,14-6+/t16-,21+,22+,23+/m0/s1

SMILES string

O=C(OC)C1=CC[C@@]2(C(O[C@@](/C=C/C=C(C(O)=O)\C)(C)[C@@H]3CC2)=O)[C@]3(OC(C)=O)CC1

InChI key

XRLYZNSOXNPKOR-CBDALDGHSA-N

biological source

Larix kaempferi

assay

≥98% (HPLC)

form

powder or crystals

storage condition

protect from light

color

white to off-white

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

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Biochem/physiol Actions

Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi. It has shown antifungal, antifertility, and antiangiogenic properties. It also may exihibit anti-cancer and anti-inflammatory properties.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLBB1866V

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Quan-Bin Han et al.
Journal of separation science, 32(2), 309-313 (2008-12-17)
In order to provide the chemical markers for the quality control of herbal medicines, four diterpenoids, pseudolaric acids A and B (PAA and PAB), and their glucosides were isolated from the methanol extract of the Chinese herb Pseudolarix kaempferi using
Min Qi et al.
European journal of pharmacology, 683(1-3), 16-26 (2012-03-15)
Pseudolaric acid B (PAB) is the primary biologically active compound isolated from the root bark of P. kaempferi Gordon. Previous studies have demonstrated that PAB arrests cells in G2/M phase in several cancer cell lines without significantly perturbing the G2/M
Bing Yu et al.
Journal of molecular medicine (Berlin, Germany), 90(8), 971-981 (2012-03-13)
We have recently discovered that c-Jun executes a non-transcriptional function to stabilize hypoxia inducible factor 1α (HIF-1α) and that pseudolaric acid B (PAB) accelerates HIF-1α degradation and phosphorylates c-Jun at Ser63/73. In this study, PAB was used as a probe
Dandan Zhao et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(4), 595-602 (2012-03-06)
Pseudolaric acid B (PAB), a natural diterpene acid present in the traditional Chinese medicinal herb Tu-Jin-Pi, exerted anticancer effects on various cancer cells. However, the effect of PAB on DU145 cells, an in vitro model of hormone-refractory prostate cancer (HRPC)
Jinghua Yu et al.
Journal of pharmacological sciences, 107(3), 295-302 (2008-07-19)
Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%
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