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Merck
CN

L8542

D-Lys-D-Leu-D-Val-D-Phe-D-Phe-D-Ala trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

D-KLVFFA

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About This Item

Empirical Formula (Hill Notation):
C38H57N7O7 · xC2HF3O2
CAS Number:
342877-55-8
Molecular Weight:
723.90 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
329817664
UNSPSC Code:
12352200
MDL number:
MFCD07784505

Key Documents

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InChI key

PFZBSKYGYWNCOL-HGIWLFAJSA-N

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@@H](NC(=O)[C@H](N)CCCCN)C(=O)N[C@H](C(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](C)C(O)=O

InChI

1S/C38H57N7O7.C2HF3O2/c1-23(2)20-29(42-33(46)28(40)18-12-13-19-39)36(49)45-32(24(3)4)37(50)44-31(22-27-16-10-7-11-17-27)35(48)43-30(21-26-14-8-6-9-15-26)34(47)41-25(5)38(51)52;3-2(4,5)1(6)7/h6-11,14-17,23-25,28-32H,12-13,18-22,39-40H2,1-5H3,(H,41,47)(H,42,46)(H,43,48)(H,44,50)(H,45,49)(H,51,52);(H,6,7)/t25-,28-,29-,30-,31-,32-;/m1./s1

assay

≥95% (HPLC)

form

powder

color

white

solubility

H2O: >1 mg/mL

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

Amyloid β40 and β42 fibrillogenesis inhibitor

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
035K4716

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Robert J Chalifour et al.
The Journal of biological chemistry, 278(37), 34874-34881 (2003-07-04)
Residues 16-20 of the beta-amyloid peptide (A beta) function as a self-recognition element during A beta assembly into fibers. Peptides containing this motif retain the ability to interact with A beta and, in some cases, potently inhibit its assembly. Replacing
Koji Aoyama et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(1), 330-341 (2017-09-15)
Pro-opiomelanocortin (POMC)-expressing neurons provide α-melanocyte-stimulating hormone (α-MSH), which stimulates melanocortin 4 receptor to induce hypophagia by AMPK inhibition in the hypothalamus. α-MSH is produced by POMC cleavage in secretory granules and released. However, it is not known yet whether any

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