L9125
L-Leucine-p-nitroanilide
leucine aminopeptidase substrate, chromogenic, ≥98% (TLC), powder
Synonym(s):
L-Leucine-4-nitroanilide
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About This Item
Empirical Formula (Hill Notation):
C12H17N3O3
CAS Number:
Molecular Weight:
251.28
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
224-047-3
MDL number:
Beilstein/REAXYS Number:
2218433
Product Name
L-Leucine-p-nitroanilide, leucine aminopeptidase substrate
InChI
1S/C12H17N3O3/c1-8(2)7-11(13)12(16)14-9-3-5-10(6-4-9)15(17)18/h3-6,8,11H,7,13H2,1-2H3,(H,14,16)/t11-/m0/s1
SMILES string
CC(C)C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O
InChI key
AXZJHDNQDSVIDR-NSHDSACASA-N
assay
≥98% (TLC)
form
powder
solubility
ethanol: 50 mg/mL
storage temp.
2-8°C
Quality Level
General description
Substrate for the colorimetric determination of leucine aminopeptidase.
Application
L-Leucine-p-nitroanilide has been used as substrate
- for the determination of intestinal leucine aminopeptidase activity of juvenile rainbow trout (Oncorhynchus mykiss)
- in insulin-regulated aminopeptidase inhibition assay
- for determining exopeptidase activity
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Infection and immunity, 64(11), 4495-4500 (1996-11-01)
The structural gene for the Vibrio cholerae leucine aminopeptidase (lap) was cloned and sequenced. The cloned DNA fragment contained a 1,503-bp open reading frame potentially encoding a 501-amino-acid polypeptide with a calculated molecular mass of 54,442 Da. The deduced amino
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Nezara viridula is a polyphagous stink bug that feeds on crops of economic importance such as corn, soybean and cotton. To increase understanding of the ability of this pest insect to feed on such diverse cropping systems, we analyzed the
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Previous studies highlighted that aminopeptidase N (APN)/CD13 acts as a scavenger in the survival of hepatocellular carcinoma (HCC) stem cells by reducing reactive oxygen species (ROS) levels. Hence, it has been proposed that APN/CD13 inhibition can increase cellular ROS levels
Natasa Bozić et al.
Electrophoresis, 26(12), 2476-2480 (2005-05-28)
A general method for detecting leucyl aminopeptidase activity after native polyacrylamide gel electrophoresis (PAGE) in situ is described. The method is based on diazotization of p-nitroaniline, liberated in the polyacrylamide gel by leucyl aminopeptidase action on leucine-p-nitroanilide (LpNA) and subsequent
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