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L9125

L-Leucine-p-nitroanilide

Name: <SC>L</SC>-Leucine-<I>p</I>-nitroanilide
Brand: SIGMA

leucine aminopeptidase substrate, chromogenic, ≥98% (TLC), powder

Synonym(s):

L-Leucine-4-nitroanilide

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₇N₃O₃

CAS Number:

4178-93-2

Molecular Weight:

251.28

NACRES:

NA.32

PubChem Substance ID:

24896516

UNSPSC Code:

12352204

EC Number:

224-047-3

MDL number:

MFCD00063681

Beilstein/REAXYS Number:

2218433

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Properties

Product Name

L-Leucine-p-nitroanilide, leucine aminopeptidase substrate

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C12H17N3O3/c1-8(2)7-11(13)12(16)14-9-3-5-10(6-4-9)15(17)18/h3-6,8,11H,7,13H2,1-2H3,(H,14,16)/t11-/m0/s1

InChI key

AXZJHDNQDSVIDR-NSHDSACASA-N

Description

General description

Substrate for the colorimetric determination of leucine aminopeptidase.

Application

L-Leucine-p-nitroanilide has been used as substrate

for the determination of intestinal leucine aminopeptidase activity of juvenile rainbow trout (Oncorhynchus mykiss)
in insulin-regulated aminopeptidase inhibition assay
for determining exopeptidase activity

pictograms

GHS07

signalword

Warning

hcodes

H317,H319

pcodes

P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.

Reishi Toshiyama et al.

Oncogene, 38(2), 244-260 (2018-08-10)

Previous studies highlighted that aminopeptidase N (APN)/CD13 acts as a scavenger in the survival of hepatocellular carcinoma (HCC) stem cells by reducing reactive oxygen species (ROS) levels. Hence, it has been proposed that APN/CD13 inhibition can increase cellular ROS levels

Detection and quantification of leucyl aminopeptidase after native electrophoresis using leucine-p-nitroanilide.

Natasa Bozić et al.

Electrophoresis, 26(12), 2476-2480 (2005-05-28)

A general method for detecting leucyl aminopeptidase activity after native polyacrylamide gel electrophoresis (PAGE) in situ is described. The method is based on diazotization of p-nitroaniline, liberated in the polyacrylamide gel by leucyl aminopeptidase action on leucine-p-nitroanilide (LpNA) and subsequent

Transcription and Activity of Digestive Enzymes of Nezara viridula Maintained on Different Plant Diets.

Pablo Emiliano Cantón et al.

Frontiers in physiology, 10, 1553-1553 (2020-01-24)

Nezara viridula is a polyphagous stink bug that feeds on crops of economic importance such as corn, soybean and cotton. To increase understanding of the ability of this pest insect to feed on such diverse cropping systems, we analyzed the

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Global Trade Item Number

SKU	GTIN
L9125-500MG	04061833966464
L9125-250MG	04061833966433
L9125-1G	04061833966426
L9125-5G	04061832908960