L9780
Lipase from human pancreas
buffered aqueous solution, ≥250 units/mg protein (Lowry)
Synonym(s):
Triacylglycerol acylhydrolase, Triacylglycerol lipase
Product Name
Lipase from human pancreas, buffered aqueous solution, ≥250 units/mg protein (Lowry)
form
buffered aqueous solution
specific activity
≥250 units/mg protein (Lowry)
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... PNLIP(5406)
Analysis Note
Protein determined by Lowry.
Application
Lipase has been used in a study to assess the effects of acidification on human milk′s cellular and nutritional content. It has also been used in a study to investigate the effect of physical training on the adipose tissue of diet-induced obesity mice.
Biochem/physiol Actions
The hormone leptin reduces pancreatic secretion and expression of lipase and has been shown to directly inhibit its activity.
Tri-, di-, and monoglycerides are hydrolyzed (in decreasing order of rate).
General description
Pancreatic lipase fulfills a key function in dietary fat absorption by hydrolyzing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids.
Other Notes
One unit will liberate 1.0 μmole of 2-monoglyceride from 1,2-diglyceride per min at pH 8.1 at 37 °C.
Physical form
Solution in 0.1 M Tris containing 0.1 M NaCl and serine protease inhibitor
Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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The effects of acidification on human milk's cellular and nutritional content
Erickson, T., et al.
Journal of Perinatology : Official Journal of the California Perinatal Association, doi: 10-doi: 10 (2012)
J M de Farias et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 45(3), 190-196 (2012-09-14)
It is well known that high-fat diets (HFDs) induce obesity and result in an increase in oxidative stress in adipose tissue, which leads to an impairment of fat mobilization by a downregulation of the lipases, such as hormone-sensitive lipase (HSL)
Nili Elinson et al.
The British journal of nutrition, 96(4), 691-696 (2006-10-03)
Leptin, a metabolic regulator of energy expenditure, exerts its peripheral effects primarily by altering lipid metabolism. The exocrine pancreas has a key role in the digestion of dietary lipids, but the role of leptin in regulating pancreatic lipases remains unknown.
J Hall et al.
The Journal of small animal practice, 54(5), 275-279 (2013-02-13)
Mushroom toxicosis is rarely diagnosed in dogs and is poorly reported in the veterinary literature. This report suggests that mushroom toxicosis is a potentially under-diagnosed condition in first opinion practice in the UK. Nine dogs with clinical signs consistent with
F K Winkler et al.
Nature, 343(6260), 771-774 (1990-02-22)
Pancreatic lipase (triacylglycerol acyl hydrolase) fulfills a key function in dietary fat absorption by hydrolysing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids. We have determined the three-dimensional structure of the human enzyme, a single-chain glycoprotein of
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