L9780
Lipase from human pancreas
buffered aqueous solution, ≥250 units/mg protein (Lowry)
Synonym(s):
Triacylglycerol acylhydrolase, Triacylglycerol lipase
form
buffered aqueous solution
specific activity
≥250 units/mg protein (Lowry)
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... PNLIP(5406)
General description
Pancreatic lipase fulfills a key function in dietary fat absorption by hydrolyzing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids.
Application
Lipase has been used in a study to assess the effects of acidification on human milk′s cellular and nutritional content. It has also been used in a study to investigate the effect of physical training on the adipose tissue of diet-induced obesity mice.
Biochem/physiol Actions
The hormone leptin reduces pancreatic secretion and expression of lipase and has been shown to directly inhibit its activity.
Tri-, di-, and monoglycerides are hydrolyzed (in decreasing order of rate).
Physical form
Solution in 0.1 M Tris containing 0.1 M NaCl and serine protease inhibitor
Analysis Note
Protein determined by Lowry.
Other Notes
One unit will liberate 1.0 μmole of 2-monoglyceride from 1,2-diglyceride per min at pH 8.1 at 37 °C.
Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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The effects of acidification on human milk's cellular and nutritional content
Erickson, T., et al.
Journal of Perinatology : Official Journal of the California Perinatal Association, doi: 10-doi: 10 (2012)
J M de Farias et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 45(3), 190-196 (2012-09-14)
It is well known that high-fat diets (HFDs) induce obesity and result in an increase in oxidative stress in adipose tissue, which leads to an impairment of fat mobilization by a downregulation of the lipases, such as hormone-sensitive lipase (HSL)
Nili Elinson et al.
The British journal of nutrition, 96(4), 691-696 (2006-10-03)
Leptin, a metabolic regulator of energy expenditure, exerts its peripheral effects primarily by altering lipid metabolism. The exocrine pancreas has a key role in the digestion of dietary lipids, but the role of leptin in regulating pancreatic lipases remains unknown.
P L Okorokov et al.
Fiziologiia cheloveka, 38(6), 105-112 (2013-02-12)
Food behavior disorderes (high fat diet) and systematic strong drinks use could be the most important causes of excess intake of intestinal endotoxin (ET) in circulation (endotoxin aggression development) and induction of inflammation. In this work we investigated antiendotoxin immunity
Mehran Howaizi et al.
Acta gastro-enterologica Belgica, 75(4), 446-447 (2013-02-14)
Acute pancreatitis has a large number of causes. Major causes are alcohol and gallstones. Toxic causes, mainly represented by medication-induced pancreatitis account for less than 2% of the cases. Cannabis is an anecdotally reported cause of acute pancreatitis. Six cases
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