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Merck
CN

M002

Proadifen hydrochloride

Synonym(s):

α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester, N,N-Diethylaminoethyl 2,2-diphenylvalerate, SKF-525A

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About This Item

Empirical Formula (Hill Notation):
C23H31NO2 · HCl
CAS Number:
62-68-0
Molecular Weight:
389.96
UNSPSC Code:
12352204
MDL number:
MFCD00055151

Key Documents

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InChI key

FHIKZROVIDCMJA-UHFFFAOYSA-N

InChI

1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H

SMILES string

Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2

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Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Toshiaki Sato et al.
International journal of pharmaceutics, 372(1-2), 33-38 (2009-01-27)
We examined the effects of metabolic inhibitors on skin permeation of edaravone. SKF-525A, diclofenac sodium (DIC) and indomethacin (IND) were added to supernatant fluid (SF) of hairless rat (HR) skin homogenate. L-Cysteine (L-Cys) and benzotriazole (BTA), as pharmaceutical additives, were
Michael R Franklin et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2539-2546 (2008-09-19)
When incubated with human liver microsomes, 2-diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) undergoes cytochrome P450 (P450)-dependent oxidative N-deethylation to the secondary amine metabolite 2-ethylaminoethyl-2,2-diphenylvalerate (SKF8742). P450-selective inhibitors indicated CYP3As catalyzed this reaction, and the deethylation rate correlated best with the CYP3A activity across a
Saloua Benmansour et al.
European journal of pharmacology, 587(1-3), 90-98 (2008-05-14)
Whereas SSRIs produce rapid blockade of the serotonin transporter (SERT) in vitro and in vivo, the onset of an observable clinical effect takes longer to occur and a variety of pharmacological effects caused by antidepressants have been speculated to be
Hang Ruan et al.
Archives of pharmacal research, 34(8), 1311-1321 (2011-09-13)
dl-Praeruptorin A (Pd-Ia) is the major active constituent of the traditional Chinese medicine Peucedanum praeruptorum Dunn. Recently it has been identified as a novel agent in the treatment and prevention of cardiovascular diseases. Accordingly, we investigated the metabolism of Pd-Ia
Wan-Ling Chang-Liao et al.
Journal of ethnopharmacology, 141(2), 668-673 (2011-08-23)
Gentiopicroside (GPS) is a secoiridoid glucoside isolated from the ethanol extract of Gentianae Radix with a content of 13%, which has been used for centuries in Chinese as a digestive aid. This study investigates the pharmacokinetics of GPS and its
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