M0807
Anti-Matrix Metalloproteinase-12, C-Terminal antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-MMP-12
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About This Item
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC (f), IP, WB
Citations:
1
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MMP12(4321)
Immunogen
synthetic peptide corresponding to the C-terminal of human matrix metalloproteinase-12 (macrophage elastase).
Biochem/physiol Actions
Reacts with reduced MMP-12. The C-terminal recognizes most active forms of MMP-12. The hemopexin domain is cleaved in the final form of MMP-12 and the antibody does not detect this final form. The zymogen is approximately 54 kDa and is quickly activated to the 45 kDa form which breaks down to a cascade of active forms, ending with a 22 kDa form.
Physical form
Solution in phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Peter LaPan et al.
BMC pulmonary medicine, 10, 40-40 (2010-08-04)
Proteolysis of matrix components, in particular elastin, is a major contributing factor to the development of lung diseases such as emphysema and chronic obstructive pulmonary disease (COPD). MMP-12 (macrophage elastase) is a protease known to be involved in the progression
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