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M0905

4-Methylumbelliferyl β-D-mannopyranoside

Name: 4-Methylumbelliferyl &#946;-<SC>D</SC>-mannopyranoside
Brand: SIGMA

≥98% (TLC), powder

Synonym(s):

4-Methylumbelliferyl β-D-mannoside

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈O₈

CAS Number:

67909-30-2

Molecular Weight:

338.31

UNSPSC Code:

12352204

PubChem Substance ID:

24896580

NACRES:

NA.32

MDL number:

MFCD00069855

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Product Name

4-Methylumbelliferyl β-D-mannopyranoside, ≥98% (TLC)

Quality Level

300

assay

≥98% (TLC)

form

powder

solubility

pyridine: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15+,16-/m1/s1

InChI key

YUDPTGPSBJVHCN-NZBFACKJSA-N

Application

4-Methylumbelliferyl β-D-mannopyranoside has been used as a fluorogenic substrate for β -mannosidase in the enzyme assay of mice tissue extracts, in cell-free translation and midgut of Lutzomyia longipalpis.

Biochem/physiol Actions

4-Methylumbelliferyl β-D-mannopyranoside is a fluorescent ligand for concanavalin A and interacts with its carbohydrate binding region. It is also a fluorogenic substrate for β-mannosidase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Binding of 4-methylumbelliferyl alpha-D-mannopyranoside to tetrameric and unmodified or derivatized dimeric concanavalin A: equilibrium studies

Loontiens FG, et al.

Biochemistry, 16(2), 159-166 (1977)

Relationship between digestive enzymes and food habit of Lutzomyia longipalpis (Diptera: Psychodidae) larvae: Characterization of carbohydrases and digestion of microorganisms.

C S Moraes et al.

Journal of insect physiology, 58(8), 1136-1145 (2012-06-12)

The sandfly Lutzomyia longipalpis (Lutz and Neiva, 1912) is the main vector of American Visceral Leishmaniasis. In spite of its medical importance and several studies concerning adult digestive physiology, biochemistry and molecular biology, very few studies have been carried out

N-Alkylated aziridines are easily-prepared, potent, specific and cell-permeable covalent inhibitors of human β-glucocerebrosidase.

B T Adams et al.

Chemical communications (Cambridge, England), 51(57), 11390-11393 (2015-06-19)

β-Glucocerebrosidase deficiency leads to Gaucher disease and is a potential marker of Parkinson's disease. We have identified N-octyl conduritol aziridine as a potent and specific covalent inactivator of GBA1 in living cells. This compound is a promising lead towards a

Cell-free translation of biofuel enzymes.

Taichi E Takasuka et al.

Methods in molecular biology (Clifton, N.J.), 1118, 71-95 (2014-01-08)

In nature, bacteria and fungi are able to utilize recalcitrant plant materials by secreting a diverse set of enzymes. While genomic sequencing efforts offer exhaustive lists of genes annotated as potential polysaccharide-degrading enzymes, biochemical and functional characterizations of the encoded

Alternative substrates for use in the detection of goats heterozygous for beta-mannosidosis.

P J Healy et al.

Research in veterinary science, 33(1), 73-75 (1982-07-01)

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Global Trade Item Number

SKU	GTIN
M0905-25MG	04061832909066
M0905-250MG	04061832909059
M0905-10MG	04061832909042
M0905-100MG	04061832909035

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