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Merck
CN

M1169

7-Methoxycoumarin-4-acetyl-Asp-Glu-Val-Asp-Ala-Pro-(2,4-dinitrophenyl)Lys

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About This Item

Empirical Formula (Hill Notation):
C50H62N10O22
CAS Number:
189696-20-6
Molecular Weight:
1155.08
NACRES:
NA.77
PubChem Substance ID:
329817860
UNSPSC Code:
12352202
MDL number:
MFCD00798785

Key Documents

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InChI

1S/C50H62N10O22/c1-24(2)43(57-44(69)31(14-15-39(62)63)54-46(71)33(22-40(64)65)53-38(61)18-26-19-42(68)82-37-21-28(81-4)11-12-29(26)37)48(73)56-34(23-41(66)67)45(70)52-25(3)49(74)58-17-7-9-35(58)47(72)55-32(50(75)76)8-5-6-16-51-30-13-10-27(59(77)78)20-36(30)60(79)80/h10-13,19-21,24-25,31-35,43,51H,5-9,14-18,22-23H2,1-4H3,(H,52,70)(H,53,61)(H,54,71)(H,55,72)(H,56,73)(H,57,69)(H,62,63)(H,64,65)(H,66,67)(H,75,76)/t25-,31-,32-,33-,34-,35-,43-/m0/s1

SMILES string

COc1ccc2C(CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCNc4ccc(cc4[N+]([O-])=O)[N+]([O-])=O)C(O)=O)=CC(=O)Oc2c1

InChI key

YOUVSUDOGAVRQX-AEAFXXELSA-N

storage temp.

−20°C

Biochem/physiol Actions

Fluorogenic substrate for caspase 3 and caspase 3-like enzymes. Cleavage at the P1 Asp residue results in continuous fluorescence at 392 nm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
067H0221

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M Enari et al.
Nature, 380(6576), 723-726 (1996-04-25)
Binding of Fas ligand or an agonistic anti-Fas antibody induces apoptosis in Fas-bearing cells. The interleukin-1Beta-converting enzyme (ICE) is a cysteine protease that is involved in apoptosis induced by various stimuli, including Fas-mediated apoptosis. Several ICE homologues have been identified

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