M121
(−)-MDO-NPA hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C20H21NO2 · xHCl
CAS Number:
Molecular Weight:
307.39 (free base basis)
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
InChI
1S/C20H21NO2.ClH/c1-2-9-21-10-8-13-4-3-5-15-18(13)16(21)11-14-6-7-17-20(19(14)15)23-12-22-17;/h3-7,16H,2,8-12H2,1H3;1H/t16-;/m1./s1
SMILES string
Cl.CCCN1CCc2cccc-3c2[C@H]1Cc4ccc5OCOc5c-34
InChI key
QRTFNNCNSYALRJ-PKLMIRHRSA-N
mp
250-252 °C
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
涉药品监管产品
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H M Maksoud et al.
Journal of chromatography, 274, 149-159 (1983-05-13)
Capillary gas chromatography combined with electron-capture detection (GC-ECD) was applied to the detection and quantitation of N-n-propylnorapomorphine (NPA) and related compounds in serum and tissue using trifluoroacetyl (TFA) derivatives. The detection limits for NPA using GC-ECD of TFA derivative extend
J L Cameron et al.
The Journal of clinical endocrinology and metabolism, 75(3), 855-860 (1992-09-01)
Administration of the dopamine receptor agonist apomorphine causes a dose-dependent increase in plasma oxytocin concentrations and dose-specific behavioral changes in rodents. To investigate whether dopamine receptor agonists will elicit similar neuroendocrine and behavioral effects in primates, we administered graded doses
G Sperk et al.
Neuropharmacology, 21(12), 1311-1316 (1982-12-01)
High performance liquid chromatography with electrochemical detection was used to assay N-n-propylnorapomorphine (NPA) and other aporphines. Pretreatment of rats with (-)10,11-methylenedioxy-N-n-propylnoraporphine (MDO-NPA) yielded dose-dependent increases in tissue levels of NPA after oral or parenteral administration. Cerebral levels of NPA significantly
(-)-10,11-Methylenedioxy-N-propylnoraporphine, an orally effective dopamine agonist and duodenal antiulcerogen in the rat.
J L Neumeyer et al.
European journal of pharmacology, 88(2-3), 273-274 (1983-03-25)
A Campbell et al.
Brain research, 403(2), 393-397 (1987-02-17)
The 10-11-methylenedioxy (MDO) derivative of S(+)N-n-propylnorapomorphine (NPA) was prepared and tested as a possible active prodrug to S(+)NPA, which we have recently found to exert in vivo activity suggestive of selective antagonism of dopamine receptors in the limbic forebrain but
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