M1256
6-Methylpurine riboside
Synonym(s):
6-Methyl-9-(1-β-D-ribofuranosyl)purine
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About This Item
Empirical Formula (Hill Notation):
C11H14N4O4
CAS Number:
Molecular Weight:
266.25
UNSPSC Code:
12352204
PubChem Substance ID:
InChI
1S/C11H14N4O4/c1-5-7-10(13-3-12-5)15(4-14-7)11-9(18)8(17)6(2-16)19-11/h3-4,6,8-9,11,16-18H,2H2,1H3
InChI key
FIGBCBGMUIGJBD-UHFFFAOYSA-N
storage temp.
−20°C
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M D Thompson et al.
Journal of medicinal chemistry, 40(5), 766-770 (1997-02-28)
A series of 2,4,6-trisubstituted-5-nitropyrimidines have been prepared and evaluated for inhibition of proliferation of L1210 and H.Ep.2 cells in vitro. The most potent compound was 6-(dibromomethyl)-2-methoxy-4-morpholino-5-nitropyrimidine (11) (L1210, IC50 = 0.32 microM; H.Ep.2, IC50 = 1.6 microM). Of the 6-substituents
B W Hughes et al.
Cancer research, 55(15), 3339-3345 (1995-08-01)
We used a gene transfer-based system to generate highly toxic purine bases in tumor cells transfected with the Escherichia coli purine nucleoside phosphorylase (PNP) gene. Because these toxic purines are membrane permeant, they mediate effective killing of neighboring cells that
K Leonhardt et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 42(4), 420-424 (1987-04-01)
6-Methylpurine, 6-methyl-9-beta-D-ribofuranosylpurine and 6-hydroxymethyl-9-beta-D-ribofuranosylpurine were isolated from mycelial cultures of Collybia maculata and their antifungal, cytotoxic and antiviral activities investigated. This is the first report on the natural occurrence of these compounds.
Adenosine phosphorylase-mediated nucleoside toxicity. Application towards the detection of mycoplasmal infection in mammalian cell cultures.
G J McGarrity et al.
Experimental cell research, 139(1), 199-205 (1982-05-01)
Michal Hocek et al.
The Journal of organic chemistry, 68(14), 5773-5776 (2003-07-04)
Fe-catalyzed cross-coupling reactions of 9-substituted or protected 2,6-dichloropurines with 1 equiv of methylmagnesium chloride gave regioselectively 2-chloro-6-methylpurines in good yields. The same reactions with 3 equiv of methylmagnesium chloride or Pd-catalyzed reactions with trimethylaluminum afforded 2,6-dimethylpurines. The 2-chloro-6-methylpurines underwent another
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