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M1318

Milnacipran hydrochloride

Name: Milnacipran hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride, F 2207, Midalcipran, Toledomin

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₂N₂O · HCl

CAS Number:

101152-94-7

Molecular Weight:

282.81

NACRES:

NA.77

PubChem Substance ID:

329817868

UNSPSC Code:

12352200

MDL number:

MFCD00901293

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

description

Relative stereochemistry, Store with desiccants

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: 19 mg/mL

originator

Cypress Bioscience

storage temp.

2-8°C

SMILES string

Cl[H].CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)c2ccccc2

InChI

1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1

InChI key

XNCDYJFPRPDERF-PBCQUBLHSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Biochem/physiol Actions

Serotonin and norepinephrine reuptake inhibitor (SNRI)

Features and Benefits

This compound was developed by Cypress Bioscience. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug.

C Moret et al.

Neuropharmacology, 24(12), 1211-1219 (1985-12-01)

The present study of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane(Z) hydrochloride, was undertaken to determine its biochemical profile. The properties of midalcipran, in inhibiting the uptake of monoamines were tested and compared with that of imipramine. In vitro, midalcipran was found to

Dual serotonin and noradrenaline uptake inhibitor class of antidepressants potential for greater efficacy or just hype?

David T Wong et al.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 58, 169-222 (2002-06-25)

Preclinical and clinical studies support the rationale that development of single molecules, which would promote serotonergic and noradrenergic neurotransmission by inhibiting simultaneously the uptake of both monoamines, would potentially result in improved antidepressant drugs. Currently, the dual inhibitors of serotonin

Pharmacological effects of milnacipran, a new antidepressant, given repeatedly on the alpha1-adrenergic and serotonergic 5-HT2A systems.

J Maj et al.

Journal of neural transmission (Vienna, Austria : 1996), 107(11), 1345-1359 (2001-01-06)

Milanacipran (MIL) is a representative of a new class of antidepressants (SNRIs) which inhibit selectively the reuptake of serotonin and noradrenaline but, in contrast to tricyclics, show no affinity for neurotransmitter receptors. The present study was aimed at determining whether

Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats.

Hiroshi Kawai et al.

Biological & pharmaceutical bulletin, 41(2), 213-219 (2018-02-02)

Biological rhythms are thought to be related to the pathogenesis and therapy of various diseases including depression. Here we investigated the influence of circadian rhythms on the antidepressant activity of the dual-action serotonin-noradrenaline reuptake inhibitor (SNRI) milnacipran. Rats administered milnacipran

Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus.

Tsugunobu Andoh et al.

Biological & pharmaceutical bulletin, 43(7), 1111-1117 (2020-07-03)

Patients with cholestatic liver diseases, such as primary biliary cirrhosis, usually suffer from pruritus. However, the pathogenesis of cholestatic pruritus is unclear, and there is no current effective treatment for it. In order to find a treatment for the condition

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Global Trade Item Number

SKU	GTIN
M1318-50MG	04061832082844
M1318-10MG	04061834038139

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