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Merck
CN

M1388

Meclocycline sulfosalicylate salt

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About This Item

Empirical Formula (Hill Notation):
C22H21ClN2O8 · C7H6O6S
CAS Number:
73816-42-9
Molecular Weight:
695.05
NACRES:
NA.85
PubChem Substance ID:
24896641
UNSPSC Code:
51284010
EC Number:
277-614-2
MDL number:
MFCD00082372

Key Documents

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InChI key

FYSVKUUNXYGFLA-FRGFDCQGSA-N

InChI

1S/C22H21ClN2O8.C7H6O6S/c1-6-9-7(23)4-5-8(26)11(9)16(27)12-10(6)17(28)14-15(25(2)3)18(29)13(21(24)32)20(31)22(14,33)19(12)30;8-6-2-1-4(14(11,12)13)3-5(6)7(9)10/h4-5,10,14-15,17,26,28-30,33H,1H2,2-3H3,(H2,24,32);1-3,8H,(H,9,10)(H,11,12,13)/t10?,14-,15+,17+,22+;/m1./s1

SMILES string

OC(=O)c1cc(ccc1O)S(O)(=O)=O.CN(C)[C@H]2[C@@H]3[C@@H](O)C4C(=C)c5c(Cl)ccc(O)c5C(=O)C4=C(O)[C@]3(O)C(=O)C(C(N)=O)=C2O

color

yellow-green powder

solubility

methanol: 10 mL, clear, very dark yellow (200 mg + 10 mL MeOH)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

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General description

Chemical structure: tetracycline

Application

Meclocycline is a tetracycline antibiotic. It is used topically for skin infections. It is used to study papulopustular acne and to study the effectiveness of oral versus topical administration.

Biochem/physiol Actions

Meclocycline sulfosalicylate prevents bacterial protein synthesis through 30S ribosome-mediated chain elongation and blocks amino-acyl tRNA A-site binding.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
050H0682

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R S Stern et al.
Archives of dermatology, 120(12), 1571-1578 (1984-12-01)
We used cost-effectiveness analysis to compare the costs, risks, and benefits of two strategies for clearing papulopustular acne; topical therapy alone as initial therapy or a combination of systemic antibiotics and topical agents used at the first visit. Patients treated
The use of antibiotics in acne therapy: oral or topical administration?
E A Eady et al.
The Journal of antimicrobial chemotherapy, 10(2), 89-115 (1982-08-01)
J V Hirschmann
Archives of dermatology, 124(11), 1691-1700 (1988-11-01)
Topical antibiotics are safe and effective in certain conditions, primarily acne, rosacea, and nasal carriage of Staphylococcus aureus. They are useful in impetigo only when it is of limited extent. Their efficacy in other pyodermas is unclear, although mupirocin is

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