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M142

Minoxidil

Synonym(s):

6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide

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About This Item

Empirical Formula (Hill Notation):
C9H15N5O
CAS Number:
38304-91-5
Molecular Weight:
209.25
EC Number:
253-874-2
UNSPSC Code:
41116107
MDL number:
MFCD00063409
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mp

272-274 °C (dec.) (lit.)

format

neat

SMILES string

NC1=CC(=NC(=N)N1O)N2CCCCC2

InChI

1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2

InChI key

ZIMGGGWCDYVHOY-UHFFFAOYSA-N

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Biochem/physiol Actions

Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Esther J van Zuuren et al.
The Cochrane database of systematic reviews, 5(5), CD007628-CD007628 (2012-05-18)
Female pattern hair loss, or androgenic alopecia, is the most common type of hair loss affecting women. It is characterised by progressive shortening of the duration of the growth phase of the hair with successive hair cycles, and progressive follicular
E J van Zuuren et al.
The British journal of dermatology, 167(5), 995-1010 (2012-10-09)
Female pattern hair loss (FPHL) or androgenic alopecia is the most common type of hair loss affecting women with reduced hair density and can have a serious psychological impact. It is characterized by progressive replacement of slow cycling terminal hair
Chester L Bowen et al.
Bioanalysis, 4(23), 2823-2832 (2012-12-12)
Stabilization of phase II metabolites is an important consideration during bioanalytical method development, method validation and sample analysis. Generic approaches to stabilize these metabolites during storage in liquid-based matrices include pH adjustment of samples prior to storage and/or temperature control;
Natasha Atanaskova Mesinkovska et al.
Dermatologic clinics, 31(1), 119-127 (2012-11-20)
Female pattern hair loss (FPHL) is the most common cause of alopecia in women. FPHL is characterized histologically with increased numbers of miniaturized, velluslike hair follicles. The goal of treatment of FPHL is to arrest hair loss progression and stimulate
Marc R Avram et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 28(10), 894-900 (2002-11-02)
Over the last decade surgical management of hair loss has become an increasingly popular and satisfying procedure for both men and women, as innovations in donor harvesting, graft size, and hairline design have resulted in consistently natural-appearing hair restoration. In
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