M1552
Matrix Metalloproteinase-9 from mouse
recombinant, expressed in NSO cells, buffered aqueous solution
Synonym(s):
105 kDa Gelatinase, Gelatinase-B, MMP-9
recombinant
expressed in NSO cells
form
buffered aqueous solution
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
mouse ... Mmp9(17395)
Biochem/physiol Actions
MMP-9 degrades the collagens, which make up the extracellular matrix; role in the control of angiogenesis.
Physical form
Solution in 50 mM Tris-HCl, 10 mM calcium chloride, 150 mM sodium chloride, and 0.05% Brij 35.
Analysis Note
The specific activity is measured by its ability to cleave a fluorescent peptide substrate and measured by excitation and emission wavelengths.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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T H Vu et al.
Cell, 93(3), 411-422 (1998-05-20)
Homozygous mice with a null mutation in the MMP-9/gelatinase B gene exhibit an abnormal pattern of skeletal growth plate vascularization and ossification. Although hypertrophic chondrocytes develop normally, apoptosis, vascularization, and ossification are delayed, resulting in progressive lengthening of the growth
M Florencia Iulita et al.
Brain : a journal of neurology, 137(Pt 3), 860-872 (2014-02-13)
Basal forebrain cholinergic neurons play a key role in cognition. This neuronal system is highly dependent on NGF for its synaptic integrity and the phenotypic maintenance of its cell bodies. Basal forebrain cholinergic neurons progressively degenerate in Alzheimer's disease and
Marzena Schiwon et al.
Cell, 156(3), 456-468 (2014-02-04)
The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and cooperation is unclear. Here, we report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C(-)
Peiying Li et al.
Stroke, 45(3), 857-864 (2014-02-06)
Our recent research revealed that adoptively transferred regulatory T cells (Tregs) reduced acute ischemic brain injury by inhibiting neutrophil-derived matrix metalloproteinase-9 (MMP-9) and protecting against blood-brain barrier damage. The mechanisms underlying Treg interactions with neutrophils remain elusive. This study evaluates
M S Hibbs et al.
The Journal of clinical investigation, 80(6), 1644-1650 (1987-12-01)
Human pulmonary alveolar macrophages obtained by bronchoalveolar lavage from both normal controls and smokers secreted in vitro a neutral proteinase that degraded denatured collagens. Optimal expression of the proteinase was detected after 3-5 d of culture. The proteinase could not
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