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Merck
CN

M157

MEN-10,376

≥95% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C57H68N12O10
CAS Number:
135306-85-3
Molecular Weight:
1081.22
NACRES:
NA.32
PubChem Substance ID:
24896670
UNSPSC Code:
51111800
MDL number:
MFCD00144736
Form:
solid
Assay:
≥95% (HPLC)

Key Documents

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Product Name

MEN-10,376, ≥95% (HPLC), solid

InChI

1S/C57H68N12O10/c1-31(2)50(69-56(78)48(26-35-30-63-43-16-8-5-13-39(35)43)67-53(75)45(23-32-18-20-36(70)21-19-32)65-52(74)40(59)27-49(71)72)57(79)68-47(25-34-29-62-42-15-7-4-12-38(34)42)55(77)66-46(24-33-28-61-41-14-6-3-11-37(33)41)54(76)64-44(51(60)73)17-9-10-22-58/h3-8,11-16,18-21,28-31,40,44-48,50,61-63,70H,9-10,17,22-27,58-59H2,1-2H3,(H2,60,73)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H,68,79)(H,69,78)(H,71,72)

SMILES string

CC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(N)CC(O)=O)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CCCCN)C(N)=O

InChI key

QQHOFZNACVKNHK-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

color

white

storage temp.

−20°C

Quality Level

200

Gene Information

human ... TACR2(6865)

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Biochem/physiol Actions

Potent and selective NK-2 tachykinin receptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBC6472V
041M1696V
041M1696
069K1725
074K11452

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M W Lewis et al.
American journal of physiology. Gastrointestinal and liver physiology, 281(1), G164-G172 (2001-06-16)
Previous evidence suggests that substance P (SP) activates subpopulations of neurons within the dorsal motor nucleus of the vagus (DMV). In this study we aimed at identifying these subpopulations in relation to their gastrointestinal projection organs or vagal branches and
Monika Sundqvist et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 291(4), R1138-R1144 (2006-05-20)
The transparent body wall of Xenopus laevis larvae during the first developmental stages allows in vivo studies of gastrointestinal tract activity. The purpose of this study was to chart the ontogeny of gut motility in Xenopus larvae and to identify
Kyle M Baumbauer et al.
Behavioral neuroscience, 121(5), 1082-1094 (2007-10-03)
Previous research has demonstrated that spinally transected rats can acquire a prolonged flexion response to prevent the delivery of shock. However, rats that receive shock irrespective of leg position cannot learn to maintain the same response. The present experiments examined
Donatella Mutolo et al.
Journal of applied physiology (Bethesda, Md. : 1985), 109(4), 1002-1010 (2010-07-24)
We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) region has a crucial role in determining both the expiratory and inspiratory components
Sean B Dolan et al.
Drug and alcohol dependence, 146, 97-102 (2014-12-08)
Dimethylamylamine (DMAA) is a component of many dietary supplements and has recently been associated with numerous adverse effects, prompting the US military and World Anti-Doping Agency to ban its use as a supplement. The current study aimed to elucidate the
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