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M157

MEN-10,376

Name: MEN-10,376
Brand: SIGMA

≥95% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):

C₅₇H₆₈N₁₂O₁₀

CAS Number:

135306-85-3

Molecular Weight:

1081.22

NACRES:

NA.32

PubChem Substance ID:

24896670

UNSPSC Code:

51111800

MDL number:

MFCD00144736

Form:

solid

Assay:

≥95% (HPLC)

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Quality Level

200

assay

≥95% (HPLC)

form

solid

color

white

storage temp.

−20°C

SMILES string

CC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(N)CC(O)=O)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CCCCN)C(N)=O

InChI

1S/C57H68N12O10/c1-31(2)50(69-56(78)48(26-35-30-63-43-16-8-5-13-39(35)43)67-53(75)45(23-32-18-20-36(70)21-19-32)65-52(74)40(59)27-49(71)72)57(79)68-47(25-34-29-62-42-15-7-4-12-38(34)42)55(77)66-46(24-33-28-61-41-14-6-3-11-37(33)41)54(76)64-44(51(60)73)17-9-10-22-58/h3-8,11-16,18-21,28-31,40,44-48,50,61-63,70H,9-10,17,22-27,58-59H2,1-2H3,(H2,60,73)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H,68,79)(H,69,78)(H,71,72)

InChI key

QQHOFZNACVKNHK-UHFFFAOYSA-N

Gene Information

human ... TACR2(6865)

Biochem/physiol Actions

Potent and selective NK-2 tachykinin receptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Depression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit.

Donatella Mutolo et al.

Journal of applied physiology (Bethesda, Md. : 1985), 109(4), 1002-1010 (2010-07-24)

We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) region has a crucial role in determining both the expiratory and inspiratory components

Neurokinin receptors modulate the impact of uncontrollable stimulation on adaptive spinal plasticity.

Kyle M Baumbauer et al.

Behavioral neuroscience, 121(5), 1082-1094 (2007-10-03)

Previous research has demonstrated that spinally transected rats can acquire a prolonged flexion response to prevent the delivery of shock. However, rats that receive shock irrespective of leg position cannot learn to maintain the same response. The present experiments examined

Ontogeny of excitatory and inhibitory control of gastrointestinal motility in the African clawed frog, Xenopus laevis.

Monika Sundqvist et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 291(4), R1138-R1144 (2006-05-20)

The transparent body wall of Xenopus laevis larvae during the first developmental stages allows in vivo studies of gastrointestinal tract activity. The purpose of this study was to chart the ontogeny of gut motility in Xenopus larvae and to identify

Proteinase-activated receptor-2 activation evokes oesophageal longitudinal smooth muscle contraction via a capsaicin-sensitive and neurokinin-2 receptor-dependent pathway.

H Liu et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 22(2), 210-216 (2009-09-11)

Intraluminal acid evokes sustained oesophageal longitudinal smooth muscle (LSM) contraction and oesophageal shortening, which may play a role in oesophageal pain and the aetiology of hiatus hernia. In the opossum model, this reflex has been shown to involve mast cell

Effects of substance P on identified neurons of the rat dorsal motor nucleus of the vagus.

M W Lewis et al.

American journal of physiology. Gastrointestinal and liver physiology, 281(1), G164-G172 (2001-06-16)

Previous evidence suggests that substance P (SP) activates subpopulations of neurons within the dorsal motor nucleus of the vagus (DMV). In this study we aimed at identifying these subpopulations in relation to their gastrointestinal projection organs or vagal branches and

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Global Trade Item Number

SKU	GTIN
M157-500UG	04061832677200

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