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M1818

Molindone hydrochloride

≥98% (HPLC), solid

Synonym(s):

3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H24N2O2 · HCl
CAS Number:
15622-65-8
Molecular Weight:
312.83
UNSPSC Code:
12352200
PubChem Substance ID:
24277995
MDL number:
MFCD01718304
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H2O: 19 mg/mL

originator

Endo

SMILES string

CCC1=C(C)NC2=C1C(C(CN3CCOCC3)CC2)=O.Cl

InChI

1S/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H

InChI key

GQWNECFJGBQMBO-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), HTR2A(3356), MAOA(4128), MAOB(4129)

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Biochem/physiol Actions

D2 dopamine receptor antagonist; MAO inhibitor.

Features and Benefits

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
014K4610V
014K4610

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Jennifer Dugan Stocks et al.
Journal of child and adolescent psychopharmacology, 22(2), 102-111 (2012-03-01)
To evaluate safety and tolerability of four doses of immediate-release molindone hydrochloride in children with attention-deficit/hyperactivity disorder (ADHD) and serious conduct problems. This open-label, parallel-group, dose-ranging, multicenter trial randomized children, aged 6-12 years, with ADHD and persistent, serious conduct problems
Unilateral auditory hallucinations in a boy with ipsilateral conductive hearing loss.
J R Brasic et al.
Journal of neurology, neurosurgery, and psychiatry, 62(3), 302-302 (1997-03-01)
Could repetitive transcranial magnetic stimulation improve neurocognition in early-onset schizophrenia spectrum disorders?
Paul E Croarkin et al.
Journal of the American Academy of Child and Adolescent Psychiatry, 51(9), 949-951 (2012-08-25)
C Recasens
L'Encephale, 27(3), 269-276 (2001-08-08)
Weight gain associated with neuroleptics or antipsychotic treatment is well known by psychiatrists, but is too rarely considered as justifying a specific treatment program. Overweight is a risk factor for somatic disorders and can have a negative influence on self-esteem
T Baptista et al.
Pharmacopsychiatry, 35(6), 205-219 (2003-01-09)
Excessive body weight gain (BWG) is a common side effect of some typical and atypical antipsychotic drugs (APs). Convergent evidence suggests a hierarchy in the magnitude of BWG that may be induced by diverse agents, being very high for clozapine
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