M1927
Matrix Metalloproteinase-2 from human fibroblasts
>95% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
72 Kd Gelatinase, 72 Kd Type IV collagenase, Gelatinase A, MMP-2
assay
>95% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
72 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MMP2(4313)
Biochem/physiol Actions
Degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.
Specifically cleaves type IV collagen, a major structural component of basement membranes.
Physical form
Solution in 10 mM sodium phosphate, pH 7.4, 250 mM sodium chloride, 2% DMSO, and 50% (v/v) glycerol.
Analysis Note
The enzyme is free of its endogenous inhibitor, TIMP-2 and other matrix metalloproteinases.
Regulatory Information
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P C Brooks et al.
Cell, 92(3), 391-400 (1998-02-26)
Angiogenesis depends on both cell adhesion and proteolytic mechanisms. In fact, matrix metalloproteinase 2 (MMP-2) and integrin alphavbeta3 are functionally associated on the surface of angiogenic blood vessels. A fragment of MMP-2, which comprises the C-terminal hemopexin-like domain, termed PEX
J C Irwin et al.
The Journal of clinical investigation, 97(2), 438-447 (1996-01-15)
Proteinases are likely effectors of endometrial menstrual breakdown. We have investigated proteinase production by human endometrial stromal cells subjected in vitro to progesterone (P) withdrawal, the physiologic stimulus for menstruation. Culture media of cells exposed to estradiol, P, or estradiol
Beiqin Yu et al.
BMC cell biology, 14, 17-17 (2013-03-21)
Fibroblasts play a critical role in tumorigenesis, tumor progression and metastasis. However, their detailed molecular characteristics and clinical significance are still elusive. TAGLN is an actin-binding protein that plays an important role in tumorigenesis. We investigated the interaction between cancer
Minggang Wei et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(1), 65-69 (2013-04-20)
The accumulation of extracellular matrix (ECM) is one of the main causes of renal fibrosis. Emerging evidence suggests that the metabolic enzyme of ECM is associated with renal fibrosis. In this study, we applied randomly controlled trial to check the
K Pichler et al.
The bone & joint journal, 95-B(4), 568-573 (2013-03-30)
Matrix metalloproteinases (MMPs), responsible for extracellular matrix remodelling and angiogenesis, might play a major role in the response of the growth plate to detrimental loads that lead to overuse injuries in young athletes. In order to test this hypothesis, human
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