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M1949

S-methyl-5′-thioadenosine phosphorylase human

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
2.4.2.28 (BRENDA, IUBMB)
Assay:
≥80% (SDS-PAGE)
Recombinant:
expressed in E. coli
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recombinant

expressed in E. coli

Quality Segment

200

assay

≥80% (SDS-PAGE)

form

solution

relevant disease(s)

cancer

shipped in

dry ice

storage temp.

−70°C

General description

N-terminal GST-tagged 57 kDa protein containing amino acids 2-end.

Application

S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors . MTAP may be a used to develop potential therapeutic strategies for hepatocellular carcinoma (HCC) since MTAP inactivation has been linked to HCC development and invasiveness .

Biochem/physiol Actions

MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation .

Physical form

Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween®-20, 10% glycerol,and 3 mM DTT.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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