M2567
Melanin Concentrating Hormone (6-17)
≥97% (HPLC), synthetic, lyophilized powder
Synonym(s):
MCH
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About This Item
Empirical Formula (Hill Notation):
C67H104N22O14S3
Molecular Weight:
1537.88
UNSPSC Code:
51111800
MDL number:
biological source
synthetic
Quality Level
sterility
non-sterile
assay
≥97% (HPLC)
form
lyophilized powder
composition
Peptide content, ≥70%
solubility
water: 1.00-1.04 mg/mL, clear, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... PMCH(5367)
General description
Melanin Concentrating Hormone (MCH) is a 19 amino acid cyclic neuropeptide. It belongs to a group of orexigenic peptides. MCH is abundantly expressed in the hypothalamus.
Application
Melanin Concentrating Hormone has been used as a hepta-decapeptide to study its effects on the reproductive axis and follicular development in female Oreochromis mossambicus.
Biochem/physiol Actions
Melanin Concentrating Hormone (MCH) functions in regulating feeding and energy homeostasis. It also plays a role in modulating arousal, promoting motivated behaviors, sleep patterns, and reproductive physiology. MCH is involved in controlling rapid eye movement (REM) sleep in rats. It acts as a nonselective agonist of melanin-concentrating hormone receptors 1 and 2 (MCHR-1 and -2).
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Patricia Lagos et al.
Brain research, 1265, 103-110 (2009-02-24)
Neurons that utilize melanin-concentrating hormone (MCH) as a neuromodulator are located in the lateral hypothalamus and incerto-hypothalamic area, and project diffusely throughout the central nervous system, including areas that participate in the generation and maintenance of the states of sleep
M A Bednarek et al.
Biochemistry, 40(31), 9379-9386 (2001-08-02)
Human melanin-concentrating hormone (hMCH) is a potent but nonselective agonist at human melanin-concentrating hormone receptors 1 and 2 (hMCH-1R and hMCH-2R, respectively). To determine the structural features of this neuropeptide which are necessary for efficient binding to and activation of
Genetic tests of biologic systems in affective disorders
E Hattori
Molecular Psychiatry (2005)