M2941
Myelin Basic Protein from mouse
≥95% (SDS-PAGE), ≥95% (confirmed by immuno-blotting), lyophilized powder (salt free)
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About This Item
UNSPSC Code:
12352202
MDL number:
biological source
mouse
assay
≥95% (SDS-PAGE), ≥95% (confirmed by immuno-blotting)
form
lyophilized powder (salt free)
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Mbp(17196)
General description
Myelin basic protein (MBP) comprises about 20% of the myelin sheath in neuronal axons. MBP is commonly used to induce autoimmune encephalomyelitis in animal models. MBP is unique in its high degree of post-translational modifications including multiple phosphorylation sites, deamidation of glutamine and acetylation of alanine as well as deimination of arginine to yield citrulline and methylation of arginine.
Application
Probably due to the presence of all known MBP isoforms and thus all potential immunological epitopes, this mouse MBP can be used to induce experimental autoimmune encephalomyelitis (EAE) in mice, a condition resembling human multiple sclerosis.It was used for substrate recognition and channeling of monomodules from the pikromycin polyketide synthase. It was also used in molecular association and monolayer formation of soluble phthalocyanine compounds.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Brian J Beck et al.
Journal of the American Chemical Society, 125(41), 12551-12557 (2003-10-09)
The unique ability of the pikromycin (Pik) polyketide synthase to generate 12- and 14-membered ring macrolactones presents an opportunity to explore the fundamental processes underlying polyketide synthesis, specifically the mechanistic details of the chain extension process. We have overexpressed and
S K Dalai et al.
Immunology, 95(1), 83-89 (1998-10-10)
Cyclosporin A (CsA) at 120 mg/kg body weight when injected subcutaneously into BALB/c mice along with thyroglobulin emulsified in incomplete Freund's adjuvant (IFA) was found to suppress antigen-specific IgG titre by 86%. Isotyping revealed that both IgG1 and IgG2a titres
Todd R Heallen et al.
Developmental cell, 15(4), 603-616 (2008-10-16)
The Aurora B kinase is the enzymatic core of the chromosomal passenger complex, which is a critical regulator of mitosis. To identify novel regulators of Aurora B, we performed a genome-wide screen for suppressors of a temperature-sensitive lethal allele of
Samriddha Ray et al.
The Journal of cell biology, 190(5), 793-805 (2010-09-02)
The mechanisms that regulate cytoskeletal remodeling during the transition between mitosis and interphase are poorly understood. In fission yeast the MOR pathway promotes actin polarization to cell tips in interphase, whereas the SIN signaling pathway drives actomyosin ring assembly and
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