M3038
Methoxypolyethylene glycol tresylate
≥65%, mol wt ~5,000
Synonym(s):
TMPEG
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About This Item
UNSPSC Code:
12161900
MDL number:
mol wt
~5,000
concentration
≥65%
storage temp.
−20°C
General description
Methoxypolyethylene glycol tresylate is a polyethylene glycol (PEG) derivative. PEGs are widely used as a covalent modifier of biologic macromolecules and particulates and for mechanism of drug delivery.
Application
Methoxypolyethylene glycol has been used in a study to assess the effect of PEGylation on Bacteriorhodopsin stability towards ethanol. It has also been used in a study to investigate hydrogel containing silica shell cross-linked micelles for drug delivery. It is also used for modification of proteins under mild conditions.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Hydrogel containing silica shell cross-linked micelles for ocular drug delivery
Lu, C., et al.
Journal of Pharmacy and Clinical Sciences, 627-637 (2012)
PEGylation of Membrane Proteins Like Bacteriorhodopsin as a Tool to Increase their Stability Towards Ethanol
Busch, A., et al.
The Journal of Physical Chemistry B, 14613-14617 (2012)
Chemistry of polyethylene glycol conjugates with biologically active molecules
Zalipsky, S., et al.
Advanced Drug Delivery Reviews, 16, 157-157 (1995)
C Delgado et al.
Biotechnology and applied biochemistry, 12(2), 119-128 (1990-04-01)
Poly(ethylene glycol) activated with tresyl chloride has been covalently linked to albumin as a result of a 2-h incubation in 0.05 M sodium phosphate buffer, pH 7.5, containing 0.125 M sodium chloride (0.344 OSM). The coupling of poly(ethylene glycol) to
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