M3152
Methoxypolyethylene glycol succinate N-hydroxysuccinimide
~50%, mol wt ~5,000
Synonym(s):
mono-Methyl polyethylene glycol succinate N-succinimidyl ester, O-Methyl-O′-succinylpolyethylene glycol 5,000 N-succinimidyl ester, PEG-succinimidyl succinate
mol wt
~5,000
concentration
~50%
storage temp.
−20°C
InChI
1S/C11H15NO7/c13-5-6-18-7-8(14)1-4-11(17)19-12-9(15)2-3-10(12)16/h13H,1-7H2
InChI key
OVPTZXRXNNJKSJ-UHFFFAOYSA-N
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Application
For protein modification. May improve solubility and extend biological lifetime.
Other Notes
Shearwater Polymers product
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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G Sirokmán et al.
Protein science : a publication of the Protein Society, 2(7), 1161-1170 (1993-07-01)
Bacteriorhodopsin (BR), from the purple membrane (PM) of Halobacterium halobium, was chemically modified with methoxypolyethylene glycol (m-PEG; molecular weight = 5,000 Da) succinimidyl carbonate. The polyethylene glycol-bacteriorhodopsin (m-PEG-SC-BR33) conjugate, containing one polyethylene glycol chain, was water soluble. The secondary structure
H Matsuyama et al.
Chemical & pharmaceutical bulletin, 39(3), 743-746 (1991-03-01)
Phospholipase D from Streptomyces sp. AA586, PLDP, was modified with methoxypolyethylene glycol succinimidylsuccinate (ss-PEG), an active derivative of polyethylene glycol. By titration with trinitrobenzene sulfonate (TNBS), approximately 70% of the free amino groups in the enzyme protein were shown to
M A Croyle et al.
Journal of virology, 75(10), 4792-4801 (2001-04-20)
Most of the early gene therapy trials for cystic fibrosis have been with adenovirus vectors. First-generation viruses with E1a and E1b deleted are limited by transient expression of the transgene and substantial inflammatory responses. Gene transfer is also significantly curtailed
Georgi As Georgiev et al.
Colloids and surfaces. B, Biointerfaces, 59(2), 184-193 (2007-06-26)
Foam thin liquid films (TLF) and monolayers at the air-water interface formed by DMPC mixed with DMPE-bonded poly (ethylene glycol)s (DMPE-PEG(550), DMPE-PEG(2000) and DMPE-PEG(5000)) were obtained. The influence of both (i) PEG chain size (evaluated in terms of Mw) and
Y P Li et al.
Acta pharmacologica Sinica, 22(6), 549-555 (2001-12-19)
To assess the merits of polyethylene glycol-modified recombinant human tumor necrosis factor alpha (PEG-rHuTNF-alpha). The rHuTNF-alpha was modified with N-succinimidyl succinate monomethoxy polyethylene glycol (SS-PEG) of three different molecular weights. The PEG-rHuTNF-alpha was separated into fractions of various molecular weights
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