M3386
1-Methylhistamine dihydrochloride
Synonym(s):
1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C6H11N3 · 2HCl
CAS Number:
Molecular Weight:
198.09
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].Cn1cnc(CCN)c1
InChI
1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
InChI key
AGXVEALMQHTMSW-UHFFFAOYSA-N
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Biochem/physiol Actions
Major metabolite of histamine by histamine N-methyltransferase.
Other Notes
Similar to M 4910, but prepared for Sigma.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Peter C Konturek et al.
Medical science monitor : international medical journal of experimental and clinical research, 14(9), CR452-CR458 (2008-09-02)
There is some evidence that Helicobacter pylori (Hp) infection may protect against asthma and allergy. The aim of the present study was to analyse the prevalence of Hp infection in adults with proven food allergy and to compare it with
Mikaël Croyal et al.
Analytical biochemistry, 409(1), 28-36 (2010-10-12)
An ultra-performance liquid chromatography tandem mass spectrometry (UPLC™-MS/MS) assay was developed for the simultaneous analysis of histamine, its major metabolite tele-methylhistamine, and an internal standard (N-tele-(R)-α-dimethylhistamine) from human cerebrospinal fluid (CSF) samples. The method involves derivatization of primary amines with
Seiichi Chiba et al.
Brain research bulletin, 79(1), 37-40 (2009-01-20)
Histamine suppresses feeding behavior via histamine H1 receptors in the hypothalamus. This study was performed to examine whether the acute reduction of histamine release in the hypothalamus caused by immepip, a histamine H3 agonist, modulates the feeding behavior of rats.
Brain histamine turnover and seizure behaviour in two mouse strains: preliminary findings.
L Tuomisto et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52 Suppl 1, S27-S28 (2003-05-21)
Yasuhisa Miyamoto et al.
Analytical biochemistry, 334(1), 89-96 (2004-10-07)
An improved high-performance liquid chromatography (HPLC) method was developed for simultaneous analysis of histamine (HA) and tele-methylhistamine (tele-MHA) levels in mouse and rat brain. The method consists of a solid-phase extraction (SPE) and subsequent HPLC with postcolumn derivatization of the
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