M3386
1-Methylhistamine dihydrochloride
Synonym(s):
1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C6H11N3 · 2HCl
CAS Number:
Molecular Weight:
198.09
UNSPSC Code:
12352204
PubChem Substance ID:
MDL number:
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].Cn1cnc(CCN)c1
InChI
1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
InChI key
AGXVEALMQHTMSW-UHFFFAOYSA-N
Biochem/physiol Actions
Major metabolite of histamine by histamine N-methyltransferase.
Other Notes
Similar to M 4910, but prepared for Sigma.
Storage Class
11 - Combustible Solids
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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M Motawaj et al.
The Journal of pharmacology and experimental therapeutics, 336(2), 479-487 (2010-11-09)
We previously reported that some N-methyl-D-aspartate (NMDA)-receptor antagonists enhanced histamine neuron activity in rodents. Here, we have investigated the effects of memantine, an NMDA-receptor antagonist used for the treatment of Alzheimer's disease, on histaminergic neurotransmission. In vitro, memantine antagonized native
Yasuhisa Miyamoto et al.
Analytical biochemistry, 334(1), 89-96 (2004-10-07)
An improved high-performance liquid chromatography (HPLC) method was developed for simultaneous analysis of histamine (HA) and tele-methylhistamine (tele-MHA) levels in mouse and rat brain. The method consists of a solid-phase extraction (SPE) and subsequent HPLC with postcolumn derivatization of the
Inability to replicate cerebrospinal fluid histamine deficits in the primary hypersomnias: a back to the drawing board moment.
David B Rye
Sleep, 35(10), 1315-1317 (2012-10-02)
Suppressed weight gain following chronic I-histidine loading--involvement of neuronal histaminergic system?
S Lensu et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52 Suppl 1, S35-S36 (2003-05-21)
Alcoholics show altered histaminergic neurotransmission in several cortical areas--preliminary report.
K Alakärppä et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52 Suppl 1, S37-S38 (2003-05-21)
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