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Merck
CN

M3398

α2-Macroglobulin from human blood plasma

Prestained

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UNSPSC Code:
12352202
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biological source

human plasma

form

powder

mol wt

unstained protein 180,000 Da

technique(s)

electrophoresis: suitable

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... A2M(2)

Biochem/physiol Actions

α2-Macroglobulin (α2M) is a multifunctional protein that is a broad spectrum protease inhibitor. α2M is a large homotetrameric glycoprotein (720 kDa) that is connected by disulfide-linked dimers which non-covalently interact to give the quaternary structure.

Regulatory Information

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E M Smergel et al.
Clinical nuclear medicine, 12(5), 349-353 (1987-05-01)
Fourteen patients with slipped capital femoral epiphysis (SCFE) who had high-resolution and magnification bone scintigraphy during treatment were studied. By demonstrating the vascular status of the femoral head and physiologic condition of the growth plate, scintigraphy was found to assist
Rafal P Piprek et al.
Differentiation; research in biological diversity, 106, 23-34 (2019-03-11)
The extracellular matrix (ECM) proteins play an important role in the establishment of the sex-dependent structure of developing gonads. The matrix metalloproteinases (MMPs) are the major players in the regulation of ECM. Our hypothesis was that the MMPs-dependent regulation of
Synnove Norvoll Magnussen et al.
BMC cancer, 17(1), 350-350 (2017-05-21)
Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously observed elevated expression of uPAR at the tumour-stroma interface in

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