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M3529

L-Methionine p-nitroanilide

Name: <SC>L</SC>-Methionine p-nitroanilide
Brand: SIGMA

≥98% (TLC), suitable for ligand binding assays

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₅N₃O₃S

CAS Number:

6042-04-2

Molecular Weight:

269.32

UNSPSC Code:

12352209

PubChem Substance ID:

24896851

NACRES:

NA.26

MDL number:

MFCD00063424

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Properties

Product Name

L-Methionine p-nitroanilide,

assay

≥98% (TLC)

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

white to faint yellow

storage temp.

−20°C

SMILES string

CSCC[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C11H15N3O3S/c1-18-7-6-10(12)11(15)13-8-2-4-9(5-3-8)14(16)17/h2-5,10H,6-7,12H2,1H3,(H,13,15)/t10-/m0/s1

InChI key

PLBWRAWSHVJPTL-JTQLQIEISA-N

Description

Biochem/physiol Actions

L-Methionine p-nitroanilide is a hMetAP2 substrate.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

049F5556

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A new colorimetric assay for methionyl aminopeptidases: examination of the binding of a new class of pseudopeptide analog inhibitors.

Sanghamitra Mitra et al.

Analytical biochemistry, 357(1), 43-49 (2006-07-18)

A direct and convenient spectrophotometric assay has been developed for methionine aminopeptidases (MetAPs). The method employs the hydrolysis of a substrate that is a methionyl analogue of p-nitroaniline (L-Met-p-NA), which releases the chromogenic product p-nitroaniline. This chromogenic product can be

Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2).

G Yang et al.

Biochemistry, 40(35), 10645-10654 (2001-08-29)

The steady-state kinetics of a full-length and truncated form of the type 2 human methionine aminopeptidase (hMetAP2) were analyzed by continuous monitoring of the amide bond cleavage of various peptide substrates and methionyl analogues of 7-amido-4-methylcoumarin (AMC) and p-nitroaniline (pNA)

Studies on the subcellular localization of protease and arylaminopeptidase activities in Streptococcus sanguis ATCC 10556.

R A Cowman et al.

Journal of dental research, 70(12), 1508-1515 (1991-12-01)

Intact cells of Streptococcus sanguis ATCC 10556 possessed arylaminopeptidases exhibiting activity toward the nitroanilide (NA) derivatives of leucine, alanine, methionine, arginine, or lysine. Weak hydrolytic activity was observed in assays with the NA derivatives of valine, proline, glycine, or glutamic

Global Trade Item Number

SKU	GTIN
M3529-1G	04061826060445
M3529-100MG	04061832417325