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M3657

4-Methylumbelliferyl α-D-mannopyranoside

Name: 4-Methylumbelliferyl &#945;-<SC>D</SC>-mannopyranoside
Brand: SIGMA

fluorogenic, ≥97% (HPLC), powder

Synonym(s):

4-methylumbelliferyl a-d-mannopyranoside, 4-methylumbelliferyl alpha-d-mannopyranoside

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈O₈

CAS Number:

28541-83-5

Molecular Weight:

338.31

NACRES:

NA.32

PubChem Substance ID:

24896865

UNSPSC Code:

12352204

EC Number:

249-073-2

MDL number:

MFCD00067662

Beilstein/REAXYS Number:

1266648

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Product Name

4-Methylumbelliferyl α-D-mannopyranoside, ≥97% (HPLC)

Quality Level

300

assay

≥97% (HPLC)

form

powder

solubility

pyridine: 20 mg/mL, clear, colorless to faintly yellow

fluorescence

λ_ex 350 nm; λ_em 375 nm (pH 7.0), λ_ex 360 nm; λ_em 449 nm (Reaction product)

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15+,16+/m1/s1

InChI key

YUDPTGPSBJVHCN-VMMWWAARSA-N

Application

4-Methylumbelliferyl α-D-mannopyranoside has been used to assay α-mannosidase activity in various biological samples.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Murine UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase lacking the gamma-subunit retains substantial activity toward acid hydrolases.

Wang-Sik Lee et al.

The Journal of biological chemistry, 282(37), 27198-27203 (2007-07-27)

UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase) mediates the first step in the synthesis of the mannose 6-phosphate recognition marker on acid hydrolases. The transferase exists as an alpha(2)beta(2)gamma(2) hexameric complex with the alpha- and beta-subunits derived from a single precursor molecule. The

Effect of the conformation of concanavalin A on its affinity for manganous ion.

A J Sophianopoulos et al.

Archives of biochemistry and biophysics, 246(2), 572-580 (1986-05-01)

The stoichiometry of Mn2+ binding to concanavalin A at pH 6.4-7 which had been established in two independent studies [J.A. Sophianopoulos, A.J. Sophianopoulos, and W.C. MacMahon (1983) Arch. Biochem. Biophys. 223, 350-359; D.J. Christie, G.R. Munske, and J.A. Magnuson (1979)

The putative role of members of the CEA-gene family (CEA, NCA an BGP) as ligands for the bacterial colonization of different human epithelial tissues.

H G Leusch et al.

Zentralblatt fur Bakteriologie : international journal of medical microbiology, 275(1), 118-122 (1991-04-01)

Immobilized purified CEA (carcinoembryonic antigen), NCA (non-specific crossreacting antigen) and BGP I (biliary glycoprotein I) bind strains of E. coli (including EPEC) and some Salmonella species (including S. typhi, S. paratyphi A + B and S. java) while Shigella-, Yersinia-

Binding of methylumbelliferyl mannoside to concanavalin A under high pressure.

R B Thompson et al.

Biochimica et biophysica acta, 790(1), 87-90 (1984-10-09)

The equilibrium binding of 4-methylumbelliferyl alpha-D-mannopyranoside to concanavalin A was measured by changes in fluorescence quenching observed at pressures ranging from 1 to 2000 bar (1974 atmospheres). From the pressure-induced changes in the apparent Ka, we calculated volume changes for

Conformational equilibrium of demetalized concanavalin A: a reexamination of the kinetics of its interaction with Ca2+-ions and fluorescent saccharide.

S H Koenig et al.

Biochemical and biophysical research communications, 109(3), 1047-1053 (1982-12-15)

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Global Trade Item Number

SKU	GTIN
M3657-10MG	04061834050483
M3657-25MG	04061832909196
M3657-100MG	04061832909172

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