M4154
β-N-Methylamino-L-alanine hydrochloride
Synonym(s):
L-BMAA
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About This Item
Empirical Formula (Hill Notation):
C4H10N2O2 · HCl
CAS Number:
Molecular Weight:
154.60
UNSPSC Code:
12352200
MDL number:
SMILES string
CNCC(N)C(O)=O
storage temp.
2-8°C
Biochem/physiol Actions
Neuroexcitotoxic amino acid; may be involved in Guam amyotrophic lateral sclerosis
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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András Guseo
Orvosi hetilap, 153(52), 2060-2069 (2012-12-25)
Parkinson's disease is one of the most frequent progressive degenerative disorders with unknown origin of the nervous system. The commutation of the disease on Guam led to the discovery of a neurotoxin which was also found in other continents. This
Travis Rush et al.
Neuroreport, 23(4), 216-219 (2012-02-09)
Determination of the environmental factors involved in neurodegenerative diseases has been elusive. Methylmercury and β-N-methylamino-L-alanine (BMAA) have both been implicated in this role. Exposure of primary cortical cultures to these compounds independently induced concentration-dependent neurotoxicity. Importantly, concentrations of BMAA (10-100
Elijah W Stommel et al.
Medical hypotheses, 80(2), 142-145 (2012-12-19)
Sporadic amyotrophic lateral sclerosis (sALS) is a fatal neurodegenerative disease with no known cause. There are many clues to suggest an environmental trigger for the disease, including reports of conjugal couples and co-localized employees that developed sALS. On the island
Shark fin consumption may expose people to neurotoxic BMAA.
Wendee Holtcamp
Environmental health perspectives, 120(5), A191-A191 (2012-05-03)
W Broc Glover et al.
Analytical chemistry, 84(18), 7946-7953 (2012-08-22)
β-methylamino-l-alanine (BMAA) is a naturally occurring nonprotein amino acid originally discovered in cycad seeds and traditional foods of the Chamorro people of Guam. Recent research has implicated BMAA as a potential factor in neurodegenerative disease and described the production of
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