M4632
2-Chloro-5,5-dimethyl-1,3-cyclohexanedione
Synonym(s):
2-Chlorodimedone
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About This Item
Empirical Formula (Hill Notation):
C8H11ClO2
CAS Number:
Molecular Weight:
174.62
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
Beilstein/REAXYS Number:
2326749
SMILES string
CC1(C)CC(=O)C(Cl)C(=O)C1
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
161-164 °C (lit.)
format
neat
storage temp.
−20°C
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General description
Substrate for chloroperoxidase.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Z S Farhangrazi et al.
Biochemistry, 31(44), 10763-10768 (1992-11-10)
Monochlorodimedone (MCD), commonly used as a halogen acceptor for haloperoxidase assays, was oxidized by hydrogen peroxide in the presence of lignin peroxidase isoenzymes H2 and H8. When oxidized, it produced a weak absorption band with an intensity that varied with
Stimulation of the chlorinating activity of human myeloperoxidase by thyroid hormones and analogues.
J M Van Zyl et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 21(8), 441-444 (1989-08-01)
Thyroxine and triiodothyronine concentrations of 50 nM or lower can stimulate the chlorinating activity of the myeloperoxidase-H2O2-Cl- antimicrobial system in vitro. The initial rates of the chlorinating reaction with monochlorodimedone were similar for both thyroid hormones. Maximum stimulation occurred around
I de Mendez et al.
Archives of biochemistry and biophysics, 289(2), 319-323 (1991-09-11)
The biochemical characteristics of endogenous macrophage peroxidases (Po), and their relationship to myeloperoxidase (MPO), have heretofore been poorly understood and were examined in the current study. Rat alveolar macrophages (AM) were homogenized and fractionated by differential centrifugation into lysosomal and
A J Kettle et al.
Free radical research communications, 12-13 Pt 1, 47-52 (1991-01-01)
Human neutrophils stimulated with opsonized zymosan promoted hypochlorous acid (HOCl)-dependent loss of monochlorodimedon. Formation of HOCl was completely inhibited by catalase, and it was also inhibited up to 70% by SOD. There was no inhibition by desferal, DTPA, mannitol or
P Barnett et al.
The Journal of biological chemistry, 273(36), 23381-23387 (1998-08-29)
Here we describe the isolation, purification, and basic kinetic parameters of a vanadium type chloroperoxidase from the hyphomycete fungus Embellisia didymospora. The enzyme proved to possess similar high substrate affinities, a Km of 5 microM for a bromide, 1.2 mM
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