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M6315

Monoclonal Anti-Mismatch Repair Protein 2 antibody produced in mouse

~1 mg/mL, clone 2MSH01, tissue culture supernatant

Synonym(s):

Anti-MSH2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00282379
Conjugate:
unconjugated
Clone:
2MSH01, monoclonal
Application:
IHC (p)
Citations:
3
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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

2MSH01, monoclonal

mol wt

antigen 102 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25

isotype

IgG1

UniProt accession no.

P43246

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MSH2(4436)

General description

Mismatch repair protein 2 (MSH2) possesses four domains and belongs to the mismatch repair (MMR) gene family. The gene encoding this protein is localized on human chromosome 2p21.

Immunogen

recombinant human mismatch repair protein 2 (MSH2).

Biochem/physiol Actions

Mismatch repair protein 2 (MSH2) plays a very important role in the DNA mismatch repair system. It repairs DNA damage which is induced by drugs. MSH2 dysfunction has been associated with nonpolyposis colorectal cancer (Lynch syndrome).

Physical form

Contains 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
042K1261

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Articles

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

Related Content

H Chen et al.
Scandinavian journal of immunology, 81(2), 121-128 (2014-11-21)
γδT cells function as sentinels in early host responses to infections and malignancies. Previously, we found ectopically expressed human MutS homologue 2 (hMSH2), recognized by γδT cells, triggered a γδT cell-mediated cytolysis to tumor cells. However, the characteristics of hMSH2-specific
Jin Zhang et al.
Oncology reports, 32(5), 2199-2206 (2014-09-02)
The objective of the present study was to investigate the association between paclitaxel resistance, gene copy number, and gene expression in ovarian carcinoma, and to restore paclitaxel sensitivity in a paclitaxel-resistant ovarian carcinoma cell line by using hMSH2-targeting siRNA. Paclitaxel-resistant
Jen-Chung Ko et al.
Biochemical and biophysical research communications, 456(1), 506-512 (2014-12-10)
The anti-estrogen tamoxifen has been used worldwide as an adjuvant hormone therapeutic agent in the treatment of breast cancer. However, the molecular mechanism of tamoxifen-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells has not been identified. Human MutS homolog

Global Trade Item Number

SKUGTIN
M6315-500UL04061836275945