M6390
Merocyanine 540
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About This Item
Empirical Formula (Hill Notation):
C26H32N3NaO6S2
CAS Number:
Molecular Weight:
569.67
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
3585252
MDL number:
InChI key
OSQUFVVXNRMSHL-LTHRDKTGSA-M
SMILES string
[Na+].CCCCN1C(=O)C(=C\C=C\C=C2/Oc3ccccc3N2CCCS([O-])(=O)=O)\C(=O)N(CCCC)C1=S
InChI
1S/C26H33N3O6S2.Na/c1-3-5-16-28-24(30)20(25(31)29(26(28)36)17-6-4-2)12-7-10-15-23-27(18-11-19-37(32,33)34)21-13-8-9-14-22(21)35-23;/h7-10,12-15H,3-6,11,16-19H2,1-2H3,(H,32,33,34);/q;+1/p-1/b10-7+,23-15-;
mp
285 °C (dec.) (lit.)
storage temp.
2-8°C
Application
Impermeant fluorescent probe for membrane potential and permeability, photoxidation of the membrane-bound dye differentially modifies membrane permeability.
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R C Meagher et al.
Journal of cellular physiology, 116(1), 118-124 (1983-07-01)
Merocyanine 540 (MC 540) is an impermeant fluorescent dye that binds preferentially to fluidlike domains of the cell membrane. Photoexcitation of membrane-bound dye causes a breakdown of the normal permeability properties of the membrane and, eventually, cell death. We have
K W Kinnally et al.
Biochemistry, 17(16), 3419-3428 (1978-08-08)
A number of cationic or anionic fluorescent dyes were investigated as possible monitors of the membrane potential of rat liver mitochondria, and giant mitochondria isolated from the liver of mice maintained on a diet containing cuprizone. The fluorescence of four
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