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Merck
CN

M6536

MPL® + TDM Adjuvant

oil

Synonym(s):

Monophosphoryl-lipid A + Trehalose dicorynomycolate adjuvant

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About This Item

UNSPSC Code:
12352203
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form

oil

storage temp.

2-8°C

General description

Each vial contains 0.5 mg monophosphoryl lipid A (detoxified endotoxin) from S. minnesota (MPL) and 0.5 mg synthetic trehalose dicorynomycolate (TDM) in 2% oil (squalene)-Tween 80-water.

Application

Ribi Adjuvant System (RAS) for use in mice.
RAS is a stable oil-in-water emulsion that may be used as an alternative to the water-in-oil emulsions. These adjuvants are derived from bacterial and mycobacterial cell wall components that have been prepared to reduce the undesirable side effects of toxicity and allergenicity, but still provide potent stimulus to the immune system.

Legal Information

MPL is a registered trademark of Corixa Corporation


Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Jun Takehisa et al.
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J Billington et al.
Journal of virology, 81(9), 4604-4614 (2007-02-16)
Stable trimeric forms of human immunodeficiency virus recombinant gp140 (rgp140) are important templates for determining the structure of the glycoprotein to assist in our understanding of HIV infection and host immune response. Such information will aid the design of therapeutic
F T Liang et al.
Infection and immunity, 69(3), 1337-1343 (2001-02-17)
VlsE, the variable surface antigen of the Lyme disease spirochete, Borrelia burgdorferi, contains two invariable domains, at the amino and carboxyl termini, respectively, which collectively account for approximately one-half of the entire molecule's length and remain unchanged during antigenic variation.