M6546
(±)-2-(p-Methoxyphenoxy)propionic acid
solid, ≥98%
Synonym(s):
PMP
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About This Item
Empirical Formula (Hill Notation):
C10H12O4
CAS Number:
Molecular Weight:
196.20
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
(±)-2-(p-Methoxyphenoxy)propionic acid, ≥98%
SMILES string
COc1ccc(OC(C)C(O)=O)cc1
InChI
1S/C10H12O4/c1-7(10(11)12)14-9-5-3-8(13-2)4-6-9/h3-7H,1-2H3,(H,11,12)
InChI key
MIEKOFWWHVOKQX-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥98%
form
solid
Quality Level
Application
(±)-2-(p-Methoxyphenoxy)propionic acid may be used as a sweet taste receptor antagonist to study its effect on allulose-induced glucagon-like peptide 1 (GLP-1) secretion rats. It may also be used to study the response of the secretin tumor cell line (STC-1) to sweetener in the presence and absence of (±)-2-(p-methoxyphenoxy)propionic acid or lactisole.
Biochem/physiol Actions
As a taste modulator, the sodium salt inhibits the perception of sweetness in humans, but not in rats.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Paolo Tommasino et al.
Frontiers in neurorobotics, 11, 65-65 (2017-12-19)
A major challenge in robotics and computational neuroscience is relative to the posture/movement problem in presence of kinematic redundancy. We recently addressed this issue using a principled approach which, in conjunction with nonlinear inverse optimization, allowed capturing postural strategies such
Li-Chun Chen et al.
Food chemistry, 212, 768-777 (2016-07-05)
The biological functions of cell membranes strongly influence the binding and transport of molecular species. We developed STC-1 cell line stably expressing the sweet taste receptor (T1R2/T1R3), and explored the possible correlation between sweeteners and membrane dipole potential of STC-1
Lilli Saarinen et al.
PloS one, 12(4), e0174898-e0174898 (2017-04-21)
Pseudomyxoma peritonei (PMP) is a subtype of mucinous adenocarcinoma mainly restricted to the peritoneal cavity and most commonly originating from the appendix. The genetic background of PMP is poorly understood and no targeted treatments are currently available for this fatal
Xiulian Li et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(3), 1220-1234 (2017-10-06)
Bleomycin is a clinically used anti-cancer drug that produces DNA breaks once inside of cells. However, bleomycin is a positively charged molecule and cannot get inside of cells by free diffusion. We previously reported that the cell surface negatively charged
David E Lanfear et al.
JACC. Heart failure, 5(11), 823-832 (2017-11-04)
This study sought to derive and validate plasma metabolite associations with survival in heart failure (HF) patients. Profiling of plasma metabolites to predict the course of HF appears promising, but validation and incremental value of these profiles are less established. Patients
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