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Merck
CN

M6661

Sigma-Aldrich

MPL® + TDM + CWS Adjuvant

oil

Synonym(s):

Monophosphoryl-lipid A + Trehalose dicorynomycolate + Cell wall skeleton adjuvant

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About This Item

UNSPSC Code:
12352203
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form

oil

storage temp.

2-8°C

General description

Each vial contains 0.5 mg monophosphoryl lipid A from S. minnesota (MPL), 0.5 mg trehalose dicorynomycolate (TDM) and 0.5 mg cell wall skeleton from a tubercule bacillus (CWS) in 2% oil-Tween 80-water. The CWS provides additional immunopotentiating activity.

Application

Ribi Adjuvant System (RAS) for use in rabbits, goats and larger animals.
RAS is a stable oil-in-water emulsion that may be used as an alternative to the water-in-oil emulsions. These adjuvants are derived from bacterial and mycobacterial cell wall components that have been prepared to reduce the undesirable side effects of toxicity and allergenicity, but still provide potent stimulus to the immune system.

Legal Information

MPL is a registered trademark of Corixa Corporation

Regulatory Information

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Ovidiu I Pop et al.
The Journal of biological chemistry, 278(40), 38428-38436 (2003-07-18)
The Tat (twin-arginine protein translocation) system initially discovered in the thylakoid membrane of chloroplasts has been described recently for a variety of eubacterial organisms. Although in Escherichia coli four Tat proteins with calculated membrane spanning domains have been demonstrated to
Birke Bartosch et al.
The Journal of general virology, 83(Pt 9), 2231-2240 (2002-08-20)
Two pig endogenous retroviruses (PERV), PERV-A and -B, productively infect human cells and are therefore considered to constitute a potential risk in pig-to-human xenotransplantation. A PCR-based cloning technique to isolate infectious PERV proviruses was established. Overlapping 3' half and 5'
Victor F Lundin et al.
Developmental biology, 313(1), 320-334 (2007-12-08)
The efficient folding of actin and tubulin in vitro and in Saccharomyces cerevisiae is known to require the molecular chaperones prefoldin and CCT, yet little is known about the functions of these chaperones in multicellular organisms. Whereas none of the

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