α₂-Macroglobulin from human plasma

Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.

This preparation does not demonstrate protease inhibitory activity, but may be useful as a marker.

α₂-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α₂-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α₂-M and protease-α₂-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α₂-M may contribute to tissue destruction during inflammation.

Serum levels of α₂-Macroglobulin (α₂-M) and protease-α₂-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis and other inflammatory diseases. It is hypothesized that the oxidant inactivation of α₂-M contributes to tissue destruction in inflammation.

Package size based on protein content

Lyophilized powder containing Tris HCl, pH 8.0 and 0.1 M sodium chloride

Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.