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Merck
CN

M7192

Sigma-Aldrich

Monoclonal Anti-Major Vault Protein antibody produced in mouse

250 μg/mL, clone MVP-37, tissue culture supernatant

Synonym(s):

Anti-LRP, Anti-Lung Resistance Protein, Anti-MVP

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About This Item

MDL number:
MFCD01633598
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

MVP-37, monoclonal

mol wt

antigen ~110 kDa

species reactivity

human

concentration

250 μg/mL

technique(s)

immunocytochemistry: 1:20-1:50 using 4% paraformaldehyde-fixed cytospin preparations
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): 1:20-1:50
western blot: 1:50

isotype

IgG2b

UniProt accession no.

Q14764

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MVP(9961)

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General description

Major vault protein (MVP) is also called lung resistance protein (LRP). It forms the outer shell of vaults (ribonucleoprotein particles present in the cytoplasm).

Immunogen

full length cloned human MVP/LRP.

Biochem/physiol Actions

Major vault protein (MVP) mediates responses of cells to stress and might play a role in multidrug resistance. It has been shown to be overexpressed in drug-resistant cancer cells.
Reacts with an internal epitope of MVP/LRP (p110).

Physical form

Supplied in serum-free culture medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
073K1024

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Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells.
Tajitsu Y
International Journal of Molecular Medicine, 32(3), 703-708 (2013)
Daniela Lötsch et al.
Oncotarget, 4(11), 1904-1918 (2013-11-19)
Despite their ubiquitous expression and high conservation during evolution, precise cellular functions of vault ribonucleoparticles, mainly built of multiple major vault protein (MVP) copies, are still enigmatic. With regard to cancer, vaults were shown to be upregulated during drug resistance

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