M7320
N-Methylhistaprodifen dioxalate salt
≥98% (HPLC), solid
Synonym(s):
N-Methyl-2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]-ethanamine dioxalate salt
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About This Item
Empirical Formula (Hill Notation):
C21H25N3 · 2 C2H2O4
CAS Number:
Molecular Weight:
499.51
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: ≥10 mg/mL, H2O: insoluble <2 mg/mL
storage temp.
2-8°C
SMILES string
OC(=O)C(O)=O.OC(=O)C(O)=O.CNCCc1c[nH]c(CCC(c2ccccc2)c3ccccc3)n1
Biochem/physiol Actions
N-Methylhistaprodifen is a H1 histamine receptor agonist.
N-Methylhistaprodifen is more potent than histamine by a factor of 3.5 on guinea pig ileum; more potent than histamine by a factor of 4.3 on guinea pig arterial H1-receptor-mediated vasoconstriction; most potent H1-receptor agonist on the guinea pig ileum out of 17 agonists tested. pEC50 = 7.24 in contraction of guinea pig ileal whole segments; pEC50 = 6.31 in contraction of guinea pig aortic segments. N-methylhistaprodifen does not stimulate H2 and H3 histamine receptors; potential use in the study of H1-receptor-mediated physiological and pathophysiological functions.
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