M7772
8-Mercaptoguanosine
crystalline
Synonym(s):
8-Thioguanosine
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About This Item
Empirical Formula (Hill Notation):
C10H13N5O5S
CAS Number:
Molecular Weight:
315.31
UNSPSC Code:
41106305
PubChem Substance ID:
EC Number:
247-402-4
MDL number:
SMILES string
NC1=NC(=O)C2=C(N1)N(C3OC(CO)C(O)C3O)C(=S)N2
form
crystalline
color
light yellow
storage temp.
2-8°C
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Biochem/physiol Actions
8-Mercaptoguanosine is used to stimulate gene activation; in CD38-activated B cells it induces activation-induced cytidine deaminase (AID) expression. 8-Mercaptoguanosine is also used as an inhibitor of enzymes such as GTP cyclohydrolase I.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Qi Wu et al.
Molecular pharmacology, 63(1), 167-173 (2002-12-19)
Thymidylate synthase (TS), a key cancer chemotherapeutic target, catalyzes the conversion of deoxyuridylate to thymidylate. TS can serve as a repressor of its own synthesis by binding to its own mRNA through TS-specific binding elements (TBEs). In this report, we
M Hikida et al.
Journal of immunology (Baltimore, Md. : 1950), 156(8), 2730-2736 (1996-04-15)
In the present paper, we investigated the requirements for the induction of IgE responses in murine B cells stimulated via surface Ig receptors by trinitrophenyl (TNP)-LPS or F(ab')2 of anti-mouse IgM (anti-mu) Abs. When murine B cells were cultured with
B L Pope et al.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy, 17(2), 98-108 (1995-02-01)
Guanine ribonucleosides with single substitutions at the C8 position (monosubstituted) or with dual substitutions at the C8 and N7 positions (disubstituted) up-regulate a spectrum of immunologic responses, including cytolytic responses to tumor cells. The current studies were undertaken to determine
T Yoneyama et al.
Archives of biochemistry and biophysics, 388(1), 67-73 (2001-05-22)
GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates the feedback inhibition of GTP cyclohydrolase I activity by (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) through protein complex formation. Since guanine and BH4 have a common pyrimidine ring structure, we examined the inhibitory effect of guanine
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