M7920
Minoxidil Sulfate
K+ channel opener, powder
Synonym(s):
U-58838
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About This Item
Empirical Formula (Hill Notation):
C9H15N5O4S
CAS Number:
Molecular Weight:
289.31
MDL number:
UNSPSC Code:
12352107
PubChem Substance ID:
NACRES:
NA.77
Product Name
Minoxidil Sulfate,
form
powder
Quality Level
originator
Johnson & Johnson
storage temp.
−20°C
SMILES string
Nc1cc(nc(N)[n+]1OS([O-])(=O)=O)N2CCCCC2
InChI
1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6H,1-5H2,(H4,10,11,12,15,16,17)
InChI key
OEOLOEUAGSPDLT-UHFFFAOYSA-N
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Application
Minoxidil sulfate (MXS) has been used as a drug agent to study its effects on alopecia in corticotropin-releasing factor over-expressing (CRF-OE) mice. It has also been used as a positive control in an assay for the culturing of rat vibrissa follicles.
Biochem/physiol Actions
Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Other Notes
Active metabolite of minoxidil.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Sang-Cheol Kim et al.
Archives of pharmacal research, 35(8), 1495-1503 (2012-09-04)
This study was conducted to evaluate the effect of Acanthopanax koreanum and acankoreoside J from A. koreanum on the promotion of hair growth. When immortalized rat vibrissa dermal papilla cells were treated with extract of A. koreanum leaves, the proliferation
R Diem et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(6), 2058-2066 (2001-03-14)
Tumor-necrosis-factor-alpha (TNF-alpha) prevented secondary death of retinal ganglion cells (RGCs) after axotomy of the optic nerve in vivo. This RGC rescue was confirmed in vitro in a mixed retinal culture model. In accordance with our previous findings, TNF-alpha decreased outward
G M Pacifici et al.
European journal of clinical pharmacology, 45(4), 337-341 (1993-01-01)
Minoxidil requires to be sulphated to exert its hypotensive effect. We report on interindividual variability in the rate of minoxidil sulphation in 118 specimens of human liver and in platelets obtained from 100 healthy subjects and 100 newborns. The frequency
S Hayashi et al.
The Journal of pharmacology and experimental therapeutics, 265(3), 1527-1533 (1993-06-01)
Patch-clamp techniques were used to study pharmacological effects of minoxidil sulfate (MNXS) on the membrane currents of enzymatically isolated guinea pig ventricular myocytes. In the whole-cell current-clamp mode, MNXS (100 microM) shortened the action potential duration without affecting the resting
F M Ashcroft et al.
Trends in pharmacological sciences, 21(11), 439-445 (2000-12-21)
K(ATP) channel openers are a diverse group of drugs with a wide range of potential therapeutic uses. Their molecular targets, the K(ATP) channels, exhibit tissue-specific responses because they possess different types of regulatory sulfonylurea receptor subunits. It is well recognized
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