M8057
p38 MAP Kinase, Non-Activated human
≥90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine-tagged), buffered aqueous glycerol solution
Synonym(s):
SAPK2a, Stress activated protein kinase 2α
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About This Item
UNSPSC Code:
12352200
MDL number:
recombinant
expressed in E. coli (N-terminal histidine-tagged)
assay
≥90% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
38 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MAPK14(1432)
Biochem/physiol Actions
p38 MAP kinase (RK, SAPK2a, Mxi2, CSBP) is an enzyme that belongs to the MAP kinase family of proteins which are activated by dual phosphorylation on tyrosine and serine residues. p38 MAP kinase is homologous to the Saccharomyces cerevisiae HOG1 protein and represents a signal transduction pathway distinct from the ERK1/ERK2 pathway and JNK pathways. Activation of p38 MAP kinase occurs in response to heat shock, osmotic stress, UV irradiation and exposure to sodium arsenite or lipopolysaccharides. p38 MAP kinase is activated by the dual specificity kinases, i.e. MKK3, MKK4 or MKK6, and subsequently phosphorylates downstream substrates such as the transcription factor ATF2 and the protein kinases MAPKAP kinase-2 and MAPKAP kinase-3.
Physical form
Solution in 20 mM Tris buffer, pH 7.4, containing 50 mM sodium chloride, 0.5 mM EGTA, 1 mM DTT, 10% glycerol (w/v) and 0.03% Brij 35
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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B Dérijard et al.
Science (New York, N.Y.), 267(5198), 682-685 (1995-02-03)
Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38 subgroups. These MAP kinase isoforms are activated by dual phosphorylation on threonine and tyrosine. Two human MAP kinase kinases (MKK3 and MKK4) were
J Raingeaud et al.
The Journal of biological chemistry, 270(13), 7420-7426 (1995-03-31)
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in response to growth factors via a Ras-dependent mechanism. In contrast, JNK
J Han et al.
The Journal of biological chemistry, 271(6), 2886-2891 (1996-02-09)
Mitogen-activated protein (MAP) kinases require dual phosphorylation on threonine and tyrosine residues in order to gain enzymatic activity. This activation is carried out by a family of enzymes known as MAP kinase kinases (MKKs or MEKs). It appears that there
A Cuenda et al.
The EMBO journal, 16(2), 295-305 (1997-01-15)
Stress-activated protein kinase-3 (SAPK3), a recently described MAP kinase family member with a wide-spread tissue distribution, was transfected into several mammalian cell lines and shown to be activated in response to cellular stresses, interleukin-1 (IL-1) and tumour necrosis factor (TNF)
J Rouse et al.
Cell, 78(6), 1027-1037 (1994-09-23)
MAPK-activated protein kinase-2 (MAPKAP kinase-2) is activated in vitro by the p42 and p44 isoforms of MAPK (p42/p44MAPK). In several cell lines, however, MAPKAP kinase-2 is activated by sodium arsenite, heat shock, or osmotic stress and not by agonists that
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