M8442
Anti-Matrix Metalloproteinase-21, C-Terminal antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-MMP-21
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About This Item
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
mouse, rat, human, Xenopus
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MMP21(118856)
mouse ... Mmp21(214766)
rat ... Mmp13(171052)
General description
Matrix metalloproteinase-21 (MMP-21) is a secreted protein expressed in fetal tissues, adult tissues and cancer cell lines. It is a 57kDa protein. The gene encoding it is localized on chromosome 10 and is made up of seven exons.
Immunogen
synthetic peptide corresponding to the carboxyterminal end of human matrix metalloproteinase 21.
Biochem/physiol Actions
By immunoblotting against the reduced protein, the antibody identifies bands at 70 kDa and 66 kDa.
Matrix metalloproteinase-21 (MMP-21) is involved in increasing the invasion capacity and metastasis property of tumors.
Physical form
Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
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Katja Ahokas et al.
Gene, 301(1-2), 31-41 (2002-12-20)
We have characterized a novel human matrix metalloproteinase (MMP-21) from human placenta DNA complementary to RNA (cDNA). The 569 amino acid translation of the cDNA includes all the typical features of an MMP family member, namely a signal sequence, a
Tiina Skoog et al.
Experimental dermatology, 15(10), 775-783 (2006-09-21)
Matrix metalloproteinase (MMP)-21 and MMP-26 (matrilysin-2) are two recently cloned epithelial metalloproteases. Here we examined their expression in various benign skin disorders, in which macrophages and fibroblasts have been implicated as well as in cultures of these cells. Expression of
Tao Wu et al.
Medical oncology (Northwood, London, England), 30(1), 323-323 (2013-01-01)
Matrix metalloproteinase-21 (MMP-21) has been shown to enhance tumor invasion and metastasis ability in some solid tumors. In the present study, we investigated the expression of MMP-21 as well as its association with overall survival of gastric cancer patients. MMP-21
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