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M9066

Sigma-Aldrich

Microsomes from Liver, Pooled

from rat(Sprague-Dawley), male

Synonym(s):

Liver microsome preparation

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10 MG
CN¥532.96
50 MG
CN¥1,783.43
100 MG
CN¥2,154.06

CN¥532.96


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10 MG
CN¥532.96
50 MG
CN¥1,783.43
100 MG
CN¥2,154.06

About This Item

UNSPSC Code:
12161501
NACRES:
NA.47

CN¥532.96


In StockDetails


Request a Bulk Order

biological source

rat (Sprague-Dawley)

Quality Level

form

liquid

packaging

vial of ~10 mg

shipped in

dry ice

storage temp.

−70°C

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1 of 4

This Item
I8260I8265I9140
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

grade

technical grade

grade

reagent grade

grade

technical grade

grade

technical grade

assay

≥80% (SDS-PAGE)

assay

~95% (HPLC)

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

General description

Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).[1]

Application

Microsomes from Liver, Pooled has been used in following studies:
  • inhibition of microsomal lipid peroxidation.[2]
  • hydroxylation of isorhynchophylline (ISOR) in rats.[3]

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis.[1] Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids.[4] Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.[3]
Source of drug metabolizing enzymes, including cytochrome P-450.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Gerlândia Neres Pontes et al.
FEMS immunology and medical microbiology, 47(3), 405-413 (2006-07-29)
We evaluated the ability of human maternal and cord serum antibodies to protect mice challenged with live Escherichia coli serotype O6:K2ac (E. coli O6). Mice received paired maternal or cord serum pools before a challenge with E. coli O6 to
Simone F A Wouters et al.
Bioconjugate chemistry, 31(3), 656-662 (2020-01-08)
Bioluminescent antibodies represent attractive detection agents in both bioanalytical assays and imaging. Currently, their preparation relies on genetic fusion of luciferases to antibodies or nonspecific chemical conjugation strategies. Here, we report a generic method to generate well-defined covalent antibody-luciferase conjugates
Chuan Chiang-Ni et al.
Frontiers in microbiology, 9, 2592-2592 (2018-11-15)
Group A streptococci (GAS) with spontaneous mutations in the CovR/CovS regulatory system are more invasive and related to severe manifestations. GAS can replicate inside phagocytic cells; therefore, phagocytic cells could serve as the niche to select invasive covS mutants. Nonetheless
K M Dziegielewska et al.
The Histochemical journal, 33(8), 443-451 (2002-04-05)
Fetuin, a foetal protein of unknown function, has been shown to be expressed in both the immune and nervous systems, especially during development. Here, we show for the first time, that fetuin is abundantly present in many cells of the
Ruben Godoy-Silva et al.
Biotechnology and bioengineering, 102(4), 1119-1130 (2008-10-30)
The effect of hydrodynamic forces on animal cell cultures, while extensively studied, still lacks significant, fundamental understanding. A previous manuscript reported on the acute exposure of CHO cells to hydrodynamic forces in a second generation convergent-divergent microfluidic device (Mollet et

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