M9426
MAP Kinase, N-terminal histidine-tagged non-activated protein from rat
≥95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, 500 U/mg (Can be activated by MEK to more than 500 units per mg)
Synonym(s):
ERK2, Extracellular-signal regulated kinase, MAPK, Mitogen activated protein kinase
biological source
rat
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized powder
specific activity
500 U/mg (Can be activated by MEK to more than 500 units per mg)
mol wt
42 kDa
UniProt accession no.
application(s)
cell analysis
storage temp.
−20°C
Quality Level
Gene Information
rat ... Mapk1(116590)
Biochem/physiol Actions
MAP kinase is a serine/threonine kinase that is activated by MEK through a phosphorylation cascade. The cascade starts with extracellular signals transmitted by growth factor-regulated receptor tyrosine kinases or G-protein coupled receptors. Dually phosphorylated (Thr and Tyr) MAP kinase translocates from the cytoplasm to the nucleus, where it phosphorylates protein transcription factors, transducing extracellular signals into genomic responses, proliferation or differentiation.
Physical form
Lyophilized powder containing Tris, pH 7.5, NaCl, and EGTA, with DTT and trehalose as stabilizers
Other Notes
One unit of activated MAP kinase will transfer 1 nmol of phosphate from ATP to myelin basic protein per min at 30 °C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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