M9440
Methyl-3,4-dephostatin
>98% (HPLC), powder
Synonym(s):
3,4-Dihydroxy-N-methyl-N-nitrosoaniline
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About This Item
Empirical Formula (Hill Notation):
C7H8N2O3
CAS Number:
Molecular Weight:
168.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
>98% (HPLC)
Form:
powder
Quality Segment
assay
>98% (HPLC)
form
powder
color
red-brown
solubility
DMSO: soluble 18 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
CN(N=O)c1ccc(O)c(O)c1
InChI
1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3
InChI key
XAKAQCMEMMZUEO-UHFFFAOYSA-N
Gene Information
human ... PTPN1(5770)
Application
Methyl-3,4-dephostatin has been used as:
- an inhibitor for methyltransferases
- a kinase-related inhibitor for human transglutaminase
- a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein
Biochem/physiol Actions
Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).
Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Datasheet
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M9440-1MG | 04061826676295 |