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M9558

Anti-Muscarinic Acetylcholine Receptor (M2) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD01324031

Key Documents

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Product Name

Anti-Muscarinic Acetylcholine Receptor (M2) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:200 using brain membranes

UniProt accession no.

P08172

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CHRM2(1129)
mouse ... Chrm2(243764)
rat ... Chrm2(81645)

Biochem/physiol Actions

Muscarinic acetylcholine receptor M2 plays an important role in regulating functions of the heart and activities like pain perception and cognition. It is regarded as a good model in GPCR (G protein-coupled receptor) biology pharmacological studies. This receptor has a function in airway remodeling and it enhances the proliferation of airway smooth muscle cells (ASM) which is induced by transforming growth factor-β (TGF-β).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Muscarinic acetylcholine receptor M2 is expressed in the heart and many other tissues. The gene encoding it is localized on human chromosome 7.

Immunogen

GST fusion protein of a part of the i3 intracellular loop of human M2 muscarinic acetylcholine receptor (mAChR) corresponding to amino acid residues 227-356.1, 2

Physical form

Lyophilized at ~0.3 mg/ml from a solution of phosphate-buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

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pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
含少量动物源组分生物产品
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Certificates of Analysis (COA)

Lot/Batch Number
MKBZ3343V
MKBS9346V
MKBS5833V
MKBR0889V
MKBR0758V

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Matthew R Stoyek et al.
American journal of physiology. Heart and circulatory physiology, 311(3), H676-H688 (2016-06-28)
The cardiac pacemaker sets the heart's primary rate, with pacemaker discharge controlled by the autonomic nervous system through intracardiac ganglia. A fundamental issue in understanding the relationship between neural activity and cardiac chronotropy is the identification of neuronal populations that
Becky J Proskocil et al.
PloS one, 5(5), e10562-e10562 (2010-05-19)
Epidemiological studies link organophosphorus pesticide (OP) exposures to asthma, and we have shown that the OPs chlorpyrifos, diazinon and parathion cause airway hyperreactivity in guinea pigs 24 hr after a single subcutaneous injection. OP-induced airway hyperreactivity involves M2 muscarinic receptor
Andrew C Kruse et al.
Nature, 504(7478), 101-106 (2013-11-22)
Despite recent advances in crystallography and the availability of G-protein-coupled receptor (GPCR) structures, little is known about the mechanism of their activation process, as only the β2 adrenergic receptor (β2AR) and rhodopsin have been crystallized in fully active conformations. Here
Hanieh Toossi et al.
Brain structure & function, 222(7), 3163-3178 (2017-03-17)
Muscle tone is regulated across sleep-wake states, being maximal in waking, reduced in slow wave sleep (SWS) and absent in paradoxical or REM sleep (PS or REMS). Such changes in tone have been recorded in the masseter muscles and shown
Yinglong Miao et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(27), 10982-10987 (2013-06-20)
G-protein-coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. Although significant advances have been made in structural studies of GPCRs, details of their activation mechanism remain unclear.
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Data Sheet - M9558

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