Anti-Muscarinic Acetylcholine Receptor (M₂) antibody produced in rabbit

Muscarinic acetylcholine receptor M2 is expressed in the heart and many other tissues. The gene encoding it is localized on human chromosome 7.

GST fusion protein of a part of the i3 intracellular loop of human M₂ muscarinic acetylcholine receptor (mAChR) corresponding to amino acid residues 227-356.^{1, 2}

Muscarinic acetylcholine receptor M2 plays an important role in regulating functions of the heart and activities like pain perception and cognition. It is regarded as a good model in GPCR (G protein-coupled receptor) biology pharmacological studies. This receptor has a function in airway remodeling and it enhances the proliferation of airway smooth muscle cells (ASM) which is induced by transforming growth factor-β (TGF-β).

Lyophilized at ~0.3 mg/ml from a solution of phosphate-buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

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