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Merck
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M9568

Anti-Muscarinic Acetylcholine Receptor M3 antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD06798471
Conjugate:
unconjugated
Clone:
polyclonal
Application:
—
Citations:
3

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

immunoblotting: 1:2,000 (using ECL on rat brain lysate.)

UniProt accession no.

P08483

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CHRM3(1131)
mouse ... Chrm3(12671)
rat ... Chrm3(24260)

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General description

Muscarinic Acetylcholine Receptor M3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
Muscarinic acetylcholine receptor M3 possesses a vestibule which is a part of a hydrophilic channel having a orthosteric binding site.

Immunogen

Synthetic peptide from the third extracellular loop of rat m3 (Accession P08483).

Biochem/physiol Actions

Muscarinic acetylcholine receptor M3 functions as a protectant in myocardial ischemia. It also has roles in smooth muscle contraction and glandular secretion. The receptor has a specific affinity for the Gq/11 family of G proteins.
Muscarinic acetylcholine receptor m3.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBH8545V
SLBH8545
SLBF5923
011M1288
067K1305

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Patricia C Borck et al.
Clinical and experimental pharmacology & physiology, 47(2), 286-293 (2019-10-21)
Here, we investigate the effects of exercise training on glucose- and cholinergic-induced insulin secretion in pancreatic islets from obese and lean rats. Male Wistar rats were treated with monosodium glutamate (MSG) for the first 5 days of life, while control (CON)
Andrew C Kruse et al.
Nature, 482(7386), 552-556 (2012-02-24)
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1-M5) share a high degree of sequence
Zhenyu Pan et al.
PloS one, 7(3), e32571-e32571 (2012-03-08)
The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury. However, the role of miRNAs in M(3)-mAChR mediated cardioprotection remains unexplored. The

Related Content

Data Sheet - M9568

Instructions

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