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M9656

H-8 dihydrochloride

>98% (HPLC)

Synonym(s):

N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H15N3O2S · 2HCl
CAS Number:
113276-94-1
Molecular Weight:
338.25
NACRES:
NA.77
PubChem Substance ID:
24278039
UNSPSC Code:
12352200
MDL number:
MFCD00036962
Assay:
>98% (HPLC)
Form:
powder
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assay

>98% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].CNCCNS(=O)(=O)c1cccc2cnccc12

InChI

1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H

InChI key

RJJLZYZEVNCZIW-UHFFFAOYSA-N

Gene Information

human ... CALCRL(10203), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Calcrl(25029)

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Biochem/physiol Actions

cAMP and cGMP-dependent protein kinase inhibitor.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000090222
0000074167
025M4746V
023M4715V
083H0691

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Guijin Ma et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 131, 110766-110766 (2020-11-07)
Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment
F Shirakawa et al.
Molecular and cellular biology, 9(6), 2424-2430 (1989-06-01)
We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interleukin-2 receptor alpha subunit, could be activated in vitro by
H Hidaka et al.
Biochemistry, 23(21), 5036-5041 (1984-10-09)
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the naphthalene ring was replaced by isoquinoline, the derivatives were no longer CaM antagonists but retained the ability to inhibit

Global Trade Item Number

SKUGTIN
M9656-5MG04061832449012

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