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Merck
CN

M9812

α-MAPI

≥95%, solid

Synonym(s):

Phe-urea-Arg-Val-Phe-CHO

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About This Item

Empirical Formula (Hill Notation):
C30H41N7O6
Molecular Weight:
595.69
UNSPSC Code:
12352200
PubChem Substance ID:
24897370
MDL number:
MFCD01675374

Key Documents

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InChI

1S/C30H41N7O6/c1-19(2)25(27(40)34-22(18-38)16-20-10-5-3-6-11-20)37-26(39)23(14-9-15-33-29(31)32)35-30(43)36-24(28(41)42)17-21-12-7-4-8-13-21/h3-8,10-13,18-19,22-25H,9,14-17H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,31,32,33)(H2,35,36,43)/t22-,23-,24-,25-/m0/s1

SMILES string

[H]C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)N[C@@H](Cc2ccccc2)C(O)=O)C(C)C

InChI key

SABSBIPNNYDZRS-QORCZRPOSA-N

assay

≥95%

form

solid

shipped in

dry ice

storage temp.

−20°C

Application

Microbial alkaline protease inhibitor that binds strongly to the active site of the HIV protease.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Structural elucidation of α-MAPI, a novel microbial alkaline proteinase inhibitor, produced by Streptomyces nigrescens.
T. Watanabe, et al.
THL, 7, 625-625 (1979)
E Sarubbi et al.
FEBS letters, 279(2), 265-269 (1991-02-25)
A novel method for discovery of HIV-1 protease inhibitors in complex biological samples has been developed. The assay is based on two specific reagents: a recombinant protein constituted by a portion of the HIV-1 Gag polyprotein comprising the p17-p24 cleavage

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