M9940
Mercaptoethylguanidine hemisulfate salt
≥98%
Synonym(s):
MEG hemisulfate salt
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About This Item
Linear Formula:
H2NC(=NH)NHSCH2CH3 · 1/2 H2SO4
CAS Number:
Molecular Weight:
168.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/2C3H9N3S.H2O4S/c2*4-3(5)6-1-2-7;1-5(2,3)4/h2*7H,1-2H2,(H4,4,5,6);(H2,1,2,3,4)
SMILES string
OS(O)(=O)=O.NC(=N)NCCS.NC(=N)NCCS
InChI key
XJKZAAUVINNNNC-UHFFFAOYSA-N
assay
≥98%
form
solid
shipped in
wet ice
storage temp.
2-8°C
Application
Selective iNOS inhibitor and scavenger of peroxynitrite.
Biochem/physiol Actions
Demonstrates potent antiinflammatory effects in an animal model of airway infection that mimics human cystic fibrosis.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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The effect of inducible nitric oxide synthase (iNOS) inhibition on smoke inhalation injury in sheep.
K Soejima et al.
Shock (Augusta, Ga.), 13(4), 261-266 (2000-04-25)
Recent studies on smoke inhalation injury have been focused on nitric oxide (NO) as an essential factor of progressive lung injury. We studied the effects of inducible nitric oxide synthase (iNOS) inhibition on inhalation injury in sheep. Sheep (n =
K Soejima et al.
American journal of respiratory and critical care medicine, 163(3 Pt 1), 745-752 (2001-03-20)
Patients with severe burn and/or smoke inhalation injury suffer both systemic and pulmonary vascular hyperpermeability. We hypothesized that nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) plays a role in the changes in microvascular permeability seen with this
Christian Kellner et al.
Cancer letters, 215(1), 43-52 (2004-09-18)
We investigated the early events involved in loss of mitochondrial membrane potential (DeltaPsi(mt)) leading to apoptosis in cells derived from patients with acute lymphocytic leukemia after exposure to phenolic antioxidants. Using the nitric oxide binding dye diaminofluorescein-FM diacetate, we found
J E Irazuzta et al.
Life sciences, 67(4), 365-372 (2000-09-26)
Reactive oxygen and nitrogen species participate in the inflammatory process during meningitis. Among them, superoxide, nitric oxide (NO), and their reaction product peroxynitrite exert cytotoxic effects. Mercaptoethylguanidine (MEG) exerts beneficial effects in in vivo inflammatory conditions by scavenging peroxynitrite and
Mustafa Ozturk et al.
Journal of pineal research, 50(1), 89-96 (2010-11-11)
Doxorubicin (DOX) and Trastuzumab (TRAST) are effective agents for the treatment of many neoplastic diseases. Cardiotoxicity is a major side effect of these drugs and limit their use. In this study, the possible protective effects of melatonin (MEL), mercaptoethylguanidine (MEG)
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