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Merck
CN

MAK004

Sigma-Aldrich

Glutamate Assay Kit

sufficient for 100 colorimetric tests

Synonym(s):

L-Glutamate Assay Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
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usage

sufficient for 100 colorimetric tests

application(s)

cosmetics
food and beverages

detection method

colorimetric

relevant disease(s)

neurological disorders; cancer

storage temp.

−20°C

General description

Glutamate, one of the two acidic proteinogenic amino acids, is also a key molecule in cellular metabolism. The synthesis of α-KG from glutamate by glutamate dehydrogenase is a key TCA cycle anaplerotic reaction. In humans, glutamate plays an important role both in amino acid degradation and disposal of excess or waste nitrogen. Within the mammalian nervous system, glutamate is the most abundant excitatory neurotransmitter. It is believed to be involved in learning and memory and may also be involved in diseases like amyotrophic lateral sclerosis, autism, some forms of mental retardation, and Alzheimer′s disease. Glutamate is present in a wide variety of foods, and has been used as a flavor enhancer in food industry.

Application

Glutamate Assay Kit has been used to determine the concentration of glutamate in cerebrospinal fluid in a rat subarachnoid hemorrhage model. It has also been used to determine cytosolic and secreted glutamate concentrations in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.
Suitable to determine glutamate concentration in a variety of samples.

Biochem/physiol Actions

Glutamate concentration is determined by an enzymatic assay, which results in a colorimetric (450 nm) product, proportional to the glutamate present.

Pictograms

Health hazardCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

Regulatory Information

低风险生物材料
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Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients.
Mishra P S, et al.
Journal of Neuroinflammation, 13(1), 212-212 (2016)
Chunyan Zhu et al.
Scientific reports, 7(1), 11935-11935 (2017-09-22)
In neuropathic pain (NP), the atrophy of hippocampus contributes to the comorbidity between pain, depression and the cognitive deficits. However, the exact mechanism underling the comorbidity, the effective control of the degenerations in hippocampus and the remission of the accompanied
Glutamate as a neurotransmitter in the healthy brain.
Zhou Y and Danbolt N C
Journal of Neural Transmission. General Section, 121(8), 799-817 (2014)
The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model.
Zhang Z, et al.
Experimental Neurology, 301, 13-25 (2018)
Glutamate, at the interface between amino acid and carbohydrate metabolism.
Brosnan J T.
The Journal of Nutrition, 130(4), 988S-990S (2000)

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